Save up -80% on Abacavir
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Ziagen
|price without discount in nearest pharmacy. Price may vary.|
We offer free Abacavir coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Abacavir every time. What are you waiting for? Claim your prescription drug card now!
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Abacavir volume of distribution
The apparent volume of distribution of abacavir after intravenous administration is approximately 0.86 +/- 0.15 L/kg, suggesting that abacavir is distributed to extravascular spaces.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Abacavir
Abacavir (ABC) is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS. (Wikipedia) Chemically, it is a synthetic carbocyclic nucleoside and is the enantiomer with 1S, 4R absolute configuration on the cyclopentene ring. In vivo, abacavir sulfate dissociates to its free base, abacavir.
Abacavir mechanism of action
Abacavir is a carbocyclic synthetic nucleoside analogue and an antiviral agent. Intracellularly, abacavir is converted by cellular enzymes to the active metabolite carbovir triphosphate, an analogue of deoxyguanosine-5′-triphosphate (dGTP). Carbovir triphosphate inhibits the activity of HIV-1 reverse transcriptase (RT) both by competing with the natural substrate dGTP and by its incorporation into viral DNA. Viral DNA growth is terminated because the incorporated nucleotide lacks a 3′-OH group, which is needed to form the 5 to 3 phosphodiester linkage essential for DNA chain elongation.
Dosage forms of Abacavir
|Abacavir Sulphate||300mg||60 Tablet||$285.00|
|Abacavir Sulphate||300mg||90 Tablet||$423.00|
|Ziagen Solution||20mg/mL||240mL Oral Solution||$159.00|
Camber Pharmaceuticals, Inc.
Human Immunodeficiency Virus
Indication of Abacavir
For the treatment of HIV-1 infection, in combination with other antiretroviral agents.
Toxicity of Abacavir
Some myocardial degeneration has been noticed in rats and mice. The most commonly reported adverse reactions of at least moderate intensity (incidence 10%) in adult HIV-1 clinical trials were nausea, headache, malaise and fatigue, nausea and vomiting, and dreams/sleep disorders. Serious hypersensitivity reactions have been associated with abacavir which has been strongly linked to the presence of the HLA-B*57:01 allele. This reaction manifests itself in patients within the first 6 weeks of treatment. Patients should be tested for the presence of this allele as recommended by the U.S Food and Drug Administration (FDA).
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