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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Abacavir

Ziagen 300 mg tablet

$10.46

tablet

* price without discount in nearest pharmacy. Price may vary.

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Abacavir volume of distribution

* 0.86 0.15 L/kg (IV administration)

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What is Abacavir

Abacavir (ABC) is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS. (Wikipedia) Chemically, it is a synthetic carbocyclic nucleoside and is the enantiomer with 1S, 4R absolute configuration on the cyclopentene ring. In vivo, abacavir sulfate dissociates to its free base, abacavir.

Abacavir mechanism of action

Abacavir is a carbocyclic synthetic nucleoside analogue and an antiviral agent. Intracellularly, abacavir is converted by cellular enzymes to the active metabolite carbovir triphosphate, an analogue of deoxyguanosine-5′-triphosphate (dGTP). Carbovir triphosphate inhibits the activity of HIV-1 reverse transcriptase (RT) both by competing with the natural substrate dGTP and by its incorporation into viral DNA. Viral DNA growth is terminated because the incorporated nucleotide lacks a 3′-OH group, which is needed to form the 5 to 3 phosphodiester linkage essential for DNA chain elongation.

Dosage forms of Abacavir

DrugDosageQuantityPrice
Abacavir Sulphate300mg60 Tablet$285.00
Abacavir Sulphate300mg90 Tablet$423.00
Ziagen Solution20mg/mL240mL Oral Solution$159.00
Ziagen300mg60 Tablet$450.00
Abacavir/Lamivudine600/300mg30 Tablet$297.00
Trizivir300/150/300mg60 Tablet$1,550.00
Prescription Generics

true

International Brands

Abacavir

Synonyms

{(1S-cis)-4-(2-amino-6-(cyclopropylamino)-9H-purin-9-yl)cyclopent-2-en-1-yl}methanol Abacavir

Manufacturers

Camber Pharmaceuticals, Inc.

CAS number

136470-78-5

UNII

WR2TIP26VS

State

solid

Affected organisms

Human Immunodeficiency Virus

Indication of Abacavir

For the treatment of HIV-1 infection, in combination with other antiretroviral agents.

Toxicity of Abacavir

Some myocardial degeneration has been noticed in rats and mice. The most commonly reported adverse reactions of at least moderate intensity (incidence 10%) in adult HIV-1 clinical trials were nausea, headache, malaise and fatigue, nausea and vomiting, and dreams/sleep disorders. Serious hypersensitivity reactions have been associated with abacavir which has been strongly linked to the presence of the HLA-B*57:01 allele. This reaction manifests itself in patients within the first 6 weeks of treatment. Patients should be tested for the presence of this allele as recommended by the U.S Food and Drug Administration (FDA).

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