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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Abciximab

Reopro 2 mg/ml vial

$155.77ml
price without discount in nearest pharmacy. Price may vary.

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Abciximab volume of distribution

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About RX24Drugs

2018 Statistics

discount card

Discount Cards 16,000+

benefit

Clients Benefit 29%

savings

Total savings $4,735,080

What is Abciximab

Abciximab is a Fab fragment of the chimeric human-murine monoclonal antibody 7E3. Abciximab binds to the glycoprotein (GP) IIb/IIIa receptor of human platelets and inhibits platelet aggregation by preventing the binding of fibrinogen, von Willebrand factor, and other adhesive molecules. It also binds to vitronectin (.v.3) receptor found on platelets and vessel wall endothelial and smooth muscle cells.

Abciximab mechanism of action

Abciximab binds to the intact platelet GPIIb/IIIa receptor, which is a member of the integrin family of adhesion receptors and the major platelet surface receptor involved in platelet aggregation. This binding is thought to involve steric hindrance and/or conformational alterations which block access of large molecules to the receptor rather than direct interaction with the RGD (arginine-glycine-aspartic acid) binding site of GPIIb/IIIa. By binding to the vitronectin receptor (also known as the .v.3 integrin), abciximab blocks effects mediated by this integrin which include cell adhesion. Furthermore, abciximab blocks Mac-1 receptor on monocytes and neutrophils thus inhibiting monocyte adhesion.

Dosage forms of Abciximab

FormRouteStrength
Injection, solutionintravenous2 mg/mL
Solutionintravenous2 mg

Prescription Generics

false

International Brands

Reopro

Synonyms

7E3 7E3 antibody

Manufacturers

Eli Lilly and Company

CAS number

143653-53-6

UNII

X85G7936GV

State

liquid

Affected organisms

Humans and other mammals

Indication of Abciximab

Abciximab is indicated as an adjunct to percutaneous coronary intervention for the prevention of cardiac ischemic complications in patients undergoing percutaneous coronary intervention and in patients with unstable angina not responding to conventional medical therapy when percutaneous coronary intervention is planned within 24 hours. Abciximab is intended for use with aspirin and heparin and has been studied only in that setting.

Toxicity of Abciximab

RX24 Drugs Disclaimer: before buying a Abciximab on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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