Save up -80% on Abiraterone

Note: this is a drug discount program, not an insurance plan.
RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Zytiga

$3,170120 tablets/250 mg
Price with discount in nearest pharmacy. Price may vary.

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We offer free Abiraterone coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Abiraterone every time. What are you waiting for? Claim your prescription drug card now!

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Abiraterone volume of distribution

Volume of distribution = 19,669 ± 13,358 L

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2018 Statistics

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Discount Cards 16,000+

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Clients Benefit 29%

savings

Total savings $4,735,080

What is Abiraterone

Abiraterone is a derivative of steroidal progesterone and is an innovative drug that offers clinical benefit to patients with hormone refractory prostate cancer. Abiraterone is administered as an acetate salt prodrug because it has a higher bioavailability and less susceptible to hydrolysis than abiraterone itself. FDA approved on April 28, 2011.

Abiraterone mechanism of action

Abiraterone is an orally active inhibitor of the steroidal enzyme CYP17A1 (17 alpha-hydroxylase/C17,20 lyase). It inhibits CYP17A1 in a selective and irreversible manner via covalent binding mechanism. CYP17A1 is an enzyme that catalyzes the biosynthesis of androgen and is highly expressed in testicular, adrenal, and prostatic tumor tissue. More specifically, abiraterone inhibits the conversion of 17-hydroxyprognenolone to dehydroepiandrosterone (DHEA) by the enzyme CYP17A1 to decrease serum levels of testosterone and other androgens.

Dosage forms of Abiraterone

FormRouteStrength
Tabletoral250 mg
Tabletoral250 mg/1
Tabletoral500 mg

Prescription Generics

false

International Brands

Zytiga

Synonyms

(3beta)-17-(Pyridin-3-yl)androsta-5,16-dien-3-ol 17-(3-Pyridyl)androsta-5,16-dien-3beta-ol

Manufacturers

Janssen Inc

CAS number

154229-19-3

UNII

G819A456D0

State

solid

Affected organisms

Humans and other mammals

Indication of Abiraterone

Used in combination with prednisone for the treatment of metastatic, castration-resistant prostate cancer.

Toxicity of Abiraterone

Toxicity is related to the blockade of 17 -hydroxylase activity. Blockade results in the accumulation of upstream mineralocorticoids like 11-deoxycorticosterone leading to secondary hyperaldosteronism. Signs of hydroaldosteronism include fluid retention and hypokalemia. Mineralocorticoid receptor antagonists may be used to treat signs and symptoms.

RX24 Drugs Disclaimer: consult your healthcare provider before buying a Abiraterone on prescription or using an RX manufacturer savings coupon. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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