Save up -80% on Abiraterone

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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Abiraterone

$

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Abiraterone volume of distribution

Vdss= 19,669 13,358 L

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What is Abiraterone

Abiraterone is a derivative of steroidal progesterone and is an innovative drug that offers clinical benefit to patients with hormone refractory prostate cancer. Abiraterone is administered as an acetate salt prodrug because it has a higher bioavailability and less susceptible to hydrolysis than abiraterone itself. FDA approved on April 28, 2011.

Abiraterone mechanism of action

Abiraterone is an orally active inhibitor of the steroidal enzyme CYP17A1 (17 alpha-hydroxylase/C17,20 lyase). It inhibits CYP17A1 in a selective and irreversible manner via covalent binding mechanism. CYP17A1 is an enzyme that catalyzes the biosynthesis of androgen and is highly expressed in testicular, adrenal, and prostatic tumor tissue. More specifically, abiraterone inhibits the conversion of 17-hydroxyprognenolone to dehydroepiandrosterone (DHEA) by the enzyme CYP17A1 to decrease serum levels of testosterone and other androgens.

Dosage forms of Abiraterone

FormRouteStrength
Tabletoral250 mg
Tabletoral250 mg/1
Tabletoral500 mg
Prescription Generics

false

International Brands

Zytiga

Synonyms

(3beta)-17-(Pyridin-3-yl)androsta-5,16-dien-3-ol 17-(3-Pyridyl)androsta-5,16-dien-3beta-ol

Manufacturers

Janssen Inc

CAS number

154229-19-3

UNII

G819A456D0

State

solid

Affected organisms

Humans and other mammals

Indication of Abiraterone

Used in combination with prednisone for the treatment of metastatic, castration-resistant prostate cancer.

Toxicity of Abiraterone

Toxicity is related to the blockade of 17 -hydroxylase activity. Blockade results in the accumulation of upstream mineralocorticoids like 11-deoxycorticosterone leading to secondary hyperaldosteronism. Signs of hydroaldosteronism include fluid retention and hypokalemia. Mineralocorticoid receptor antagonists may be used to treat signs and symptoms.

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