Save up -80% on Abiraterone
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Zytiga
|$3,170||120 tablets/250 mg|
|Price with discount in nearest pharmacy. Price may vary.|
We offer free Abiraterone coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Abiraterone every time. What are you waiting for? Claim your prescription drug card now!
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Abiraterone volume of distribution
Volume of distribution = 19,669 ± 13,358 L
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Abiraterone
Abiraterone is a derivative of steroidal progesterone and is an innovative drug that offers clinical benefit to patients with hormone refractory prostate cancer. Abiraterone is administered as an acetate salt prodrug because it has a higher bioavailability and less susceptible to hydrolysis than abiraterone itself. FDA approved on April 28, 2011.
Abiraterone mechanism of action
Abiraterone is an orally active inhibitor of the steroidal enzyme CYP17A1 (17 alpha-hydroxylase/C17,20 lyase). It inhibits CYP17A1 in a selective and irreversible manner via covalent binding mechanism. CYP17A1 is an enzyme that catalyzes the biosynthesis of androgen and is highly expressed in testicular, adrenal, and prostatic tumor tissue. More specifically, abiraterone inhibits the conversion of 17-hydroxyprognenolone to dehydroepiandrosterone (DHEA) by the enzyme CYP17A1 to decrease serum levels of testosterone and other androgens.
Dosage forms of Abiraterone
Humans and other mammals
Indication of Abiraterone
Used in combination with prednisone for the treatment of metastatic, castration-resistant prostate cancer.
Toxicity of Abiraterone
Toxicity is related to the blockade of 17 -hydroxylase activity. Blockade results in the accumulation of upstream mineralocorticoids like 11-deoxycorticosterone leading to secondary hyperaldosteronism. Signs of hydroaldosteronism include fluid retention and hypokalemia. Mineralocorticoid receptor antagonists may be used to treat signs and symptoms.
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