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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Campral

$26.3760 tablets/333mg
price without discount in nearest pharmacy. Price may vary.

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Acamprosate volume of distribution

The volume of distribution for acamprosate following intravenous administration is estimated to be 72-109 liters (approximately 1 L/kg). Plasma protein binding of acamprosate is negligible. After oral dosing of 2 x 333 mg of CAMPRAL, the terminal half-life ranges from approximately 20 – 33 hours.

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2018 Statistics

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Discount Cards 16,000+

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Clients Benefit 29%

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Total savings $4,735,080

What is Acamprosate

Acamprosate, also known by the brand name Campraltrade;, is a drug used for treating alcohol dependence. Acamprosate is thought to stabilize the chemical balance in the brain that would otherwise be disrupted by alcoholism, possibly by blocking glutaminergic N-methyl-D-aspartate receptors, while gamma-aminobutyric acid type A receptors are activated. Reports indicate that acamprosate only works with a combination of attending support groups and abstinence from alcohol. Certain serious side effects include allergic reactions, irregular heartbeats, and low or high blood pressure, while less serious side effects include headaches, insomnia, and impotence. Acamprosate should not be taken by people with kidney problems or allergies to the drug.

Acamprosate mechanism of action

The mechanism of action of acamprosate in maintenance of alcohol abstinence is not completely understood. Chronic alcohol exposure is hypothesized to alter the normal balance between neuronal excitation and inhibition. iin vitro /i and iin vivo /i studies in animals have provided evidence to suggest acamprosate may interact with glutamate and GABA neurotransmitter systems centrally, and has led to the hypothesis that acamprosate restores this balance. It seems to inhibit NMDA receptors while activating GABA receptors.

Dosage forms of Acamprosate

DrugDosageQuantityPrice
Campral333mg168 Enteric Coated Tablet$98.00

Prescription Generics

true

International Brands

Acamprosate Calcium

Synonyms

3-Acetamido-1-propanesulfonic acid Acamprosato

Manufacturers

Mylan Institutional Inc.

CAS number

77337-76-9

UNII

N4K14YGM3J

State

solid

Affected organisms

Humans and other mammals

Indication of Acamprosate

For the maintenance of abstinence from alcohol in patients with alcohol dependence who are abstinent at treatment initiation

Toxicity of Acamprosate

In all reported cases of acute overdosage with acamprosate (total reported doses of up to 56 grams of acamprosate calcium), the only symptom that could be reasonably associated with acamprosate was diarrhea.

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