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RX BIN: 015558
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Acenocoumarol

Sintrom 4 mg Tablet



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Acenocoumarol volume of distribution

The volume of distribution at steady-state appeared to be significantly dose dependent: 78 ml/kg for doses or = 20 microg/kg and 88 ml/kg for doses 20 microg/kg respectively

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What is Acenocoumarol

Acenocoumarol is a coumarin derivative used as an anticoagulant. Coumarin derivatives inhibit the reduction of vitamin K by vitamin K reductase. This prevents carboxylation of vitamin K-dependent clotting factors, II, VII, XI and X, and interferes with coagulation. Hematocrit, hemoglobin, international normalized ratio and liver panel should be monitored. Patients on acenocoumarol are prohibited from giving blood.

Acenocoumarol mechanism of action

Acenocoumarol inhibits vitamin K reductase, resulting in depletion of the reduced form of vitamin K (vitamin KH2). As vitamin K is a cofactor for the carboxylation of glutamate residues on the N-terminal regions of vitamin K-dependent clotting factors, this limits the gamma-carboxylation and subsequent activation of the vitamin K-dependent coagulant proteins. The synthesis of vitamin K-dependent coagulation factors II, VII, IX, and X and anticoagulant proteins C and S is inhibited resulting in decreased prothrombin levels and a decrease in the amount of thrombin generated and bound to fibrin. This reduces the thrombogenicity of clots.

Dosage forms of Acenocoumarol

Form Route Strength
Tablet oral 1 mg
Tablet oral 4 mg
Prescription Generics


International Brands



3-(alpha-(4′-Nitrophenyl)-beta-acetylethyl)-4-hydroxycoumarin 3-(alpha-(P-Nitrophenol)-beta-acetylethyl)-4-hydroxycoumarin


Paladin Labs Inc

CAS number






Affected organisms

Humans and other mammals

Indication of Acenocoumarol

For the treatment and prevention of thromboembolic diseases. More specifically, it is indicated for the for the prevention of cerebral embolism, deep vein thrombosis, pulmonary embolism, thromboembolism in infarction and transient ischemic attacks. It is used for the treatment of deep vein thrombosis and myocardial infarction.

Toxicity of Acenocoumarol

The onset and severity of the symptoms are dependent on the individual’s sensitivity to oral anticoagulants, the severity of the overdosage, and the duration of treatment. Bleeding is the major sign of toxicity with oral anticoagulant drugs. The most frequent symptoms observed are: cutaneous bleeding (80%), haematuria (with renal colic) (52%), haematomas, gastrointestinal bleeding, haematemesis, uterine bleeding, epistaxis, gingival bleeding and bleeding into the joints. Further symptoms include tachycardia, hypotension, peripheral circulatory disorders due to loss of blood, nausea, vomiting, diarrhoea and abdominal pains.

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