Save up -80% on Acetaminophen

Note: this is a drug discount program, not an insurance plan.
RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Tylenol

$1.9130 tablets/325 mg
price without discount in nearest pharmacy. Price may vary.

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We offer free Tylenol coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Acetaminophen every time. What are you waiting for? Claim your prescription drug card now!

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Acetaminophen volume of distribution

It distributes rapidly and evenly throughout most tissues and fluids and has a volume of distribution of approximately 0.9L/kg. 10 to 20% of the drug is bound to red blood cells. Paracetamol is extensively metabolised (predominantly in the liver), the major metabolites being the sulphate and glucuronide conjugates.

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Total savings $4,735,080

What is Acetaminophen

Acetaminophen, also known as paracetamol, is commonly used for its analgesic and antipyretic effects. Its therapeutic effects are similar to salicylates, but it lacks anti-inflammatory, antiplatelet, and gastric ulcerative effects.

Acetaminophen mechanism of action

Acetaminophen is thought to act primarily in the CNS, increasing the pain threshold by inhibiting both isoforms of cyclooxygenase, COX-1, COX-2, and COX-3 enzymes involved in prostaglandin (PG) synthesis. Unlike NSAIDs, acetaminophen does not inhibit cyclooxygenase in peripheral tissues and, thus, has no peripheral anti-inflammatory affects. While aspirin acts as an irreversible inhibitor of COX and directly blocks the enzyme’s active site, studies have found that acetaminophen indirectly blocks COX, and that this blockade is ineffective in the presence of peroxides. This might explain why acetaminophen is effective in the central nervous system and in endothelial cells but not in platelets and immune cells which have high levels of peroxides. Studies also report data suggesting that acetaminophen selectively blocks a variant of the COX enzyme that is different from the known variants COX-1 and COX-2. This enzyme is now referred to as COX-3. Its exact mechanism of action is still poorly understood, but future research may provide further insight into how it works. The antipyretic properties of acetaminophen are likely due to direct effects on the heat-regulating centres of the hypothalamus resulting in peripheral vasodilation, sweating and hence heat dissipation.

Dosage forms of Acetaminophen

DrugDosageQuantityPrice
Tylenol Regular325mg100 Tablet$16.76
Tylenol Extra Strength500mg100 Tablet$18.61
Tylenol Infant DropsnoDose24mL Drops$14.90
Tylenol Arthritis Pain650mg100 Timed Release Caplets$22.49
Tylenol Childrens Suspension Grape80mg/5mL100mL Syrup (PMS)$14.41
Tylenol325mg96 Tablet (PMS)$34.20
Tylenol Ultra Relief Migrane500mg/65mg20 Tablet$13.20
Acetaminophen500mg100 Tablet$24.00
Robaxacet400/325mg40 Tablet$44.50
Robaxacet Extra Strength400/500mg72 Tablet$74.40
Methocarbamol/Acetaminophen400/500mg18 Caplet$34.00
Tempra Drops Banana80mg/mL24mL Drops (Banana)$15.30
Tempra Chewable Tablets80mg24 Chewable Tablet$12.30
Tempra Syrup Cherry160mg/5mL100mL Syrup (Cherry)$13.42

Prescription Generics

false

International Brands

(extra Strength) Acetaminophen, Caffeine 8mg Codeine Phosphate Caplets

Synonyms

4-(Acetylamino) phenol 4-acetamidophenol

Manufacturers

Stanley Pharmaceuticals, A Division Of Vita Health Products Inc.

CAS number

103-90-2

UNII

362O9ITL9D

State

solid

Affected organisms

Humans and other mammals

Indication of Acetaminophen

For temporary relief of fever, minor aches, and pains.

Toxicity of Acetaminophen

Oral, mouse: LD50 = 338 mg/kg; Oral, rat: LD50 = 1944 mg/kg. Acetaminophen is metabolized primarily in the liver, where most of it is converted to inactive compounds by conjugation with glucuronic acid and, to a lesser extent, sulfuric acid. Conjugates are then excreted by the kidneys. Only a small portion is excreted in unchanged in urine or oxidized via the hepatic cytochrome P450 enzyme system (CYP2E1). Metabolism via CYP2E1 produces a toxic metabolite, N-acetyl-p-benzoquinoneimine (NAPQI). The toxic effects of acetaminophen are due to NAPQI, not acetaminophen itself nor any of the major metabolites. At therapeutic doses, NAPQI reacts with the sulfhydryl group of glutathione to produce a non-toxic conjugate that is excreted by the kidneys. High doses of acetaminophen may cause glutathione depletion, accumulation of NAPQI and hepatic necrosis. The maximum daily dose of acetaminophen is 4 g. Liver failure has been observed at doses as low as 6 g per day. As such, the maximum daily and single dose of acetaminophen is currently being reviewed in some countries. N-acetyl-cysteine, a precursor of glutathione, may be administered in the event of acetaminophen toxicity.

RX24 Drugs Disclaimer: consult your healthcare provider before buying a Acetaminophen on prescription or using an RX manufacturer savings coupon. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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What is Tylenol?

Tylenol is a painkiller and feverish gearbox and is used to treat many conditions, such as headache, muscle aches, arthritis, back pain, toothaches, colds and fevers. You should not use Tylenol if you have severe liver disease.

Do not take more Tylenol than recommended. An overdose of acetaminophen can damage your liver or cause death. Call your doctor right away if you have nausea, pain in the upper stomach, itching, loss of appetite, dark urine, clay-colored stools or jaundice (yellowing of the skin or eyes).

Ask your doctor or pharmacist before using any other drugs to treat colds, allergies, pain, or sleep. Acetaminophen (sometimes abbreviated as APAP) is found in many combination medications. Taking certain foods together can cause you to get too much acetaminophen, which can lead to a fatal overdose. Check the label to see if the medicine contains acetaminophen or APAP.

In rare cases, Tylenol can cause a strong skin reaction. Stop taking this medicine and call your doctor right away if you have reddened skin or a rash that spreads and causes swelling and flaking.