Save up -80% on Acetaminophen
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Tylenol
|$1.91||30 tablets/325 mg|
|price without discount in nearest pharmacy. Price may vary.|
We offer free Tylenol coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Acetaminophen every time. What are you waiting for? Claim your prescription drug card now!
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Acetaminophen volume of distribution
It distributes rapidly and evenly throughout most tissues and fluids and has a volume of distribution of approximately 0.9L/kg. 10 to 20% of the drug is bound to red blood cells. Paracetamol is extensively metabolised (predominantly in the liver), the major metabolites being the sulphate and glucuronide conjugates.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Acetaminophen
Acetaminophen, also known as paracetamol, is commonly used for its analgesic and antipyretic effects. Its therapeutic effects are similar to salicylates, but it lacks anti-inflammatory, antiplatelet, and gastric ulcerative effects.
Acetaminophen mechanism of action
Acetaminophen is thought to act primarily in the CNS, increasing the pain threshold by inhibiting both isoforms of cyclooxygenase, COX-1, COX-2, and COX-3 enzymes involved in prostaglandin (PG) synthesis. Unlike NSAIDs, acetaminophen does not inhibit cyclooxygenase in peripheral tissues and, thus, has no peripheral anti-inflammatory affects. While aspirin acts as an irreversible inhibitor of COX and directly blocks the enzyme’s active site, studies have found that acetaminophen indirectly blocks COX, and that this blockade is ineffective in the presence of peroxides. This might explain why acetaminophen is effective in the central nervous system and in endothelial cells but not in platelets and immune cells which have high levels of peroxides. Studies also report data suggesting that acetaminophen selectively blocks a variant of the COX enzyme that is different from the known variants COX-1 and COX-2. This enzyme is now referred to as COX-3. Its exact mechanism of action is still poorly understood, but future research may provide further insight into how it works. The antipyretic properties of acetaminophen are likely due to direct effects on the heat-regulating centres of the hypothalamus resulting in peripheral vasodilation, sweating and hence heat dissipation.
Dosage forms of Acetaminophen
|Tylenol Regular||325mg||100 Tablet||$16.76|
|Tylenol Extra Strength||500mg||100 Tablet||$18.61|
|Tylenol Infant Drops||noDose||24mL Drops||$14.90|
|Tylenol Arthritis Pain||650mg||100 Timed Release Caplets||$22.49|
|Tylenol Childrens Suspension Grape||80mg/5mL||100mL Syrup (PMS)||$14.41|
|Tylenol||325mg||96 Tablet (PMS)||$34.20|
|Tylenol Ultra Relief Migrane||500mg/65mg||20 Tablet||$13.20|
|Robaxacet Extra Strength||400/500mg||72 Tablet||$74.40|
|Tempra Drops Banana||80mg/mL||24mL Drops (Banana)||$15.30|
|Tempra Chewable Tablets||80mg||24 Chewable Tablet||$12.30|
|Tempra Syrup Cherry||160mg/5mL||100mL Syrup (Cherry)||$13.42|
4-(Acetylamino) phenol 4-acetamidophenol
Stanley Pharmaceuticals, A Division Of Vita Health Products Inc.
Humans and other mammals
Indication of Acetaminophen
For temporary relief of fever, minor aches, and pains.
Toxicity of Acetaminophen
Oral, mouse: LD50 = 338 mg/kg; Oral, rat: LD50 = 1944 mg/kg. Acetaminophen is metabolized primarily in the liver, where most of it is converted to inactive compounds by conjugation with glucuronic acid and, to a lesser extent, sulfuric acid. Conjugates are then excreted by the kidneys. Only a small portion is excreted in unchanged in urine or oxidized via the hepatic cytochrome P450 enzyme system (CYP2E1). Metabolism via CYP2E1 produces a toxic metabolite, N-acetyl-p-benzoquinoneimine (NAPQI). The toxic effects of acetaminophen are due to NAPQI, not acetaminophen itself nor any of the major metabolites. At therapeutic doses, NAPQI reacts with the sulfhydryl group of glutathione to produce a non-toxic conjugate that is excreted by the kidneys. High doses of acetaminophen may cause glutathione depletion, accumulation of NAPQI and hepatic necrosis. The maximum daily dose of acetaminophen is 4 g. Liver failure has been observed at doses as low as 6 g per day. As such, the maximum daily and single dose of acetaminophen is currently being reviewed in some countries. N-acetyl-cysteine, a precursor of glutathione, may be administered in the event of acetaminophen toxicity.
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What is Tylenol?
Tylenol is a painkiller and feverish gearbox and is used to treat many conditions, such as headache, muscle aches, arthritis, back pain, toothaches, colds and fevers. You should not use Tylenol if you have severe liver disease.
Do not take more Tylenol than recommended. An overdose of acetaminophen can damage your liver or cause death. Call your doctor right away if you have nausea, pain in the upper stomach, itching, loss of appetite, dark urine, clay-colored stools or jaundice (yellowing of the skin or eyes).
Ask your doctor or pharmacist before using any other drugs to treat colds, allergies, pain, or sleep. Acetaminophen (sometimes abbreviated as APAP) is found in many combination medications. Taking certain foods together can cause you to get too much acetaminophen, which can lead to a fatal overdose. Check the label to see if the medicine contains acetaminophen or APAP.
In rare cases, Tylenol can cause a strong skin reaction. Stop taking this medicine and call your doctor right away if you have reddened skin or a rash that spreads and causes swelling and flaking.