Save up -80% on Acetazolamide
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Diamox
|$51.35||60 tablets/250 mg|
|price without discount in nearest pharmacy. Price may vary.|
We offer free Acetazolamide coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Acetazolamide every time. What are you waiting for? Claim your prescription drug card now!
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Acetazolamide volume of distribution
The volume of distribution of acetazolamide is 0.2 L/kg
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Acetazolamide
One of the carbonic anhydrase inhibitors that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)
Acetazolamide mechanism of action
The anticonvulsant activity of Acetazolamide may depend on a direct inhibition of carbonic anhydrase in the CNS, which decreases carbon dioxide tension in the pulmonary alveoli, thus increasing arterial oxygen tension. The diuretic effect depends on the inhibition of carbonic anhydrase, causing a reduction in the availability of hydrogen ions for active transport in the renal tubule lumen. This leads to alkaline urine and an increase in the excretion of bicarbonate, sodium, potassium, and water.
Dosage forms of Acetazolamide
|Capsule, extended release||oral||500 mg/1|
|Injection, powder, lyophilized, for solution||intravenous||500 mg/5mL|
Valeant Canada Lp Valeant Canada S.E.C.
Humans and other mammals
Indication of Acetazolamide
For adjunctive treatment of: edema due to congestive heart failure; drug-induced edema; centrencephalic epilepsies; chronic simple (open-angle) glaucoma
Toxicity of Acetazolamide
Numerous animal studies have demonstrated that the toxicity of acetazolamide was very low in the species studied (mouse, dog, rat, monkey). In the mouse, the LD50 is 3000 to 6000 mg/kg.
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