Save up -80% on Acetazolamide
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2018 Price of Acetazolamide
AcetaZOLAMIDE 500 mg 12 Hour Capsule
* price without discount in nearest pharmacy. Price may vary.
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Acetazolamide volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Acetazolamide
One of the carbonic anhydrase inhibitors that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)
Acetazolamide mechanism of action
The anticonvulsant activity of Acetazolamide may depend on a direct inhibition of carbonic anhydrase in the CNS, which decreases carbon dioxide tension in the pulmonary alveoli, thus increasing arterial oxygen tension. The diuretic effect depends on the inhibition of carbonic anhydrase, causing a reduction in the availability of hydrogen ions for active transport in the renal tubule lumen. This leads to alkaline urine and an increase in the excretion of bicarbonate, sodium, potassium, and water.
Dosage forms of Acetazolamide
|Capsule, extended release||oral||500 mg/1|
|Injection, powder, lyophilized, for solution||intravenous||500 mg/5mL|
Valeant Canada Lp Valeant Canada S.E.C.
Humans and other mammals
Toxicity of Acetazolamide
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