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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Acetazolamide

AcetaZOLAMIDE 500 mg 12 Hour Capsule

$4.46

capsule

* price without discount in nearest pharmacy. Price may vary.

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Acetazolamide volume of distribution

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What is Acetazolamide

One of the carbonic anhydrase inhibitors that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)

Acetazolamide mechanism of action

The anticonvulsant activity of Acetazolamide may depend on a direct inhibition of carbonic anhydrase in the CNS, which decreases carbon dioxide tension in the pulmonary alveoli, thus increasing arterial oxygen tension. The diuretic effect depends on the inhibition of carbonic anhydrase, causing a reduction in the availability of hydrogen ions for active transport in the renal tubule lumen. This leads to alkaline urine and an increase in the excretion of bicarbonate, sodium, potassium, and water.

Dosage forms of Acetazolamide

FormRouteStrength
Capsule, extended releaseoral500 mg/1
Injection, powder, lyophilized, for solutionintravenous500 mg/5mL
Tabletoral125 mg/1
Prescription Generics

false

International Brands

Acetazolam

Synonyms

2-acetylamino-1,3,4-Thiadiazole-5-sulfonamide 5-ACETAMIDO-1,3,4-thiadiazole-2-sulfonamide

Manufacturers

Valeant Canada Lp Valeant Canada S.E.C.

CAS number

59-66-5

UNII

O3FX965V0I

State

solid

Affected organisms

Humans and other mammals

Indication of Acetazolamide

For adjunctive treatment of: edema due to congestive heart failure; drug-induced edema; centrencephalic epilepsies; chronic simple (open-angle) glaucoma

Toxicity of Acetazolamide

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