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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Vosol

$17.571 ear dropper 15ml/2%
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Acetic acid volume of distribution

The mean volume of distribution and clearance were 52 +/- 4 l/m2 and 2.6 +/- 0.2 l/h x m2, respectively.

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What is Acetic acid

Acetic acid is a product of the oxidation of ethanol and of the destructive distillation of wood. It is used locally, occasionally internally, as a counterirritant and also as a reagent. (Stedman, 26th ed) Acetic acid otic (for the ear) is an antibiotic that treats infections caused by bacteria or fungus.

Acetic acid mechanism of action

Acetic Acid is a synthetic carboxylic acid with antibacterial and antifungal properties. Although its mechanism of action is not fully known, undissociated acetic acid may enhance lipid solubility allowing increased fatty acid accumulation on the cell membrane or in other cell wall structures.

Dosage forms of Acetic acid

FormRouteStrength
Irrigantirrigation.25 g/100mL
Irrigantirrigation250 mg/100mL
Solutionauricular (otic).02 mg/mL

Prescription Generics

false

International Brands

Acetasol HC

Synonyms

ACETATE ion Acetic acid, glacial

Manufacturers

Actavis Mid Atlantic LLC

CAS number

64-19-7

UNII

Q40Q9N063P

State

solid

Affected organisms

Bacteria

Indication of Acetic acid

Acetic acid is used to treat an outer ear infection (external otitis). It works by stopping the growth of bacteria and fungus. Treating the infection reduces pain and swelling in the ear.

Toxicity of Acetic acid

Acetic acid is absorbed from the gastrointestinal tract and through the lungs and almost completely oxidized by tissues. The metabolic pathways are reasonably well known and involve the formation of ketone bodies. As little as 1.0 mL of glacial acetic acid has resulted in perforation of the esophagus. During acetic acid dialysis, patients showed a frequent onset of sudden hypotension and arrhythmia with concomitant symptoms of the so-called disequilibrium syndrome. Extreme eye and nasal irritation has occurred at concentrations in excess of 25 ppm and conjunctivitis from concentrations below 10 ppm has been reported. Glacial acetic acid has caused permanent corneal opacification. Ingestion of 200 mL of an 80% solution of acetic acid caused repeated shock due to myocardial infarction and massive intestinal bleeding led to an organic brain psychosyndrome. The patient survived the intoxication by use of hemodialysis and intensive care therapy. An excess of prostate cancer was observed among former chemical plant workers, some of whom had been exposed to both acetic acid and acetic anhydride.

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