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Price of Acetohydroxamic Acid
Lithostat 250 mg tablet
* price without discount in nearest pharmacy. Price may vary.
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Acetohydroxamic Acid volume of distribution
What is Acetohydroxamic Acid
Acetohydroxamic Acid, a synthetic drug derived from hydroxylamine and ethyl acetate, is similar in structure to urea. In the urine, it acts as an antagonist of the bacterial enzyme urease. Acetohydroxamic Acid has no direct antimicrobial action and does not acidify urine directly. It is used, in addition to antibiotics or medical procedures, to treat chronic urea-splitting urinary infections.
Acetohydroxamic Acid mechanism of action
Acetohydroxamic Acid reversibly inhibits the bacterial enzyme urease. This inhibits the hydrolysis of urea and production of ammonia in urine infected with urea-splitting organisms, leading to a decrease in pH and ammonia levels. As antimicrobial agents are more effective in such conditions, the effectiveness of these agents is amplified, resulting in a higher cure rate.
Dosage forms of Acetohydroxamic Acid
Mission Pharmacal Company
Enteric bacteria and other eubacteria
Indication of Acetohydroxamic Acid
Used, in addition to antibiotics or medical procedures, to treat chronic urea-splitting urinary infections.
Toxicity of Acetohydroxamic Acid
Oral, rat: LD sub50 /sub = 4.8gm/kg. Symptoms of overdose include anorexia, malaise, lethargy, diminished sense of wellbeing, tremor, anxiety, nausea, and vomiting.
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