Save up -80% on Acetylsalicylic acid
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|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
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2019 Price of Acetylsalicylic acid
Entrophen 10 650 mg Enteric-Coated Tablet
|price without discount in nearest pharmacy. Price may vary.|
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Acetylsalicylic acid volume of distribution
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What is Acetylsalicylic acid
The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Acetylsalicylic acid also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
Acetylsalicylic acid mechanism of action
The analgesic, antipyretic, and anti-inflammatory effects of acetylsalicylic acid are due to actions by both the acetyl and the salicylate portions of the intact molecule as well as by the active salicylate metabolite. Acetylsalicylic acid directly and irreversibly inhibits the activity of both types of cyclooxygenase (COX-1 and COX-2) to decrease the formation of precursors of prostaglandins and thromboxanes from arachidonic acid. This makes acetylsalicylic acid different from other NSAIDS (such as diclofenac and ibuprofen) which are reversible inhibitors. Salicylate may competitively inhibit prostaglandin formation. Acetylsalicylic acid’s antirheumatic (nonsteroidal anti-inflammatory) actions are a result of its analgesic and anti-inflammatory mechanisms; the therapeutic effects are not due to pituitary-adrenal stimulation. The platelet aggregation-inhibiting effect of acetylsalicylic acid specifically involves the compound’s ability to act as an acetyl donor to cyclooxygenase; the nonacetylated salicylates have no clinically significant effect on platelet aggregation. Irreversible acetylation renders cyclooxygenase inactive, thereby preventing the formation of the aggregating agent thromboxane A2 in platelets. Since platelets lack the ability to synthesize new proteins, the effects persist for the life of the exposed platelets (7-10 days). Acetylsalicylic acid may also inhibit production of the platelet aggregation inhibitor, prostacyclin (prostaglandin I2), by blood vessel endothelial cells; however, inhibition prostacyclin production is not permanent as endothelial cells can produce more cyclooxygenase to replace the non-functional enzyme.
Dosage forms of Acetylsalicylic acid
|Aspirin Enteric Coated||81mg||30 Enteric Coated Tablet||$20.50|
|Aspirin Enteric Coated||81mg||120 Enteric Coated Tablet||$35.00|
|Aspirin Enteric Coated||325mg||100 Enteric Coated Caplets||$24.00|
|Aspirin Extra Strength||500mg||50 Tablet||$12.60|
|Aspirin Extra Strength||500mg||100 Tablet||$16.18|
10 Person Ansi
2-(ACETYLOXY)benzoic acid 2-Acetoxybenzenecarboxylic acid
Genuine First Aid LLC
Humans and other mammals
Indication of Acetylsalicylic acid
For use in the temporary relief of various forms of pain, inflammation associated with various conditions (including rheumatoid arthritis, juvenile rheumatoid arthritis, systemic lupus erythematosus, osteoarthritis, and ankylosing spondylitis), and is also used to reduce the risk of death and/or nonfatal myocardial infarction in patients with a previous infarction or unstable angina pectoris.
Toxicity of Acetylsalicylic acid
Oral, mouse: LD sub 50 /sub = 250 mg/kg; Oral, rabbit: LD sub 50 /sub = 1010 mg/kg; Oral, rat: LD sub 50 /sub = 200 mg/kg. Effects of overdose include: tinnitus, abdominal pain, hypokalemia, hypoglycemia, pyrexia, hyperventilation, dysrhythmia, hypotension, hallucination, renal failure, confusion, seizure, coma, and death.
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