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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Zovirax

$9.6330 tablets/400mg
price without discount in nearest pharmacy. Price may vary.

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Acyclovir volume of distribution

The volume of distribution at steady state was 2.96 ± 2.09 liters/kg. Total plasma concentration-versus-time plot (mean + SD) of acyclovir in six horses during and following a 1-h constant-rate infusion of acyclovir at a dose of 10 mg/kg.

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What is Acyclovir

A guanosine analog antiviral drug that acts as an antimetabolite. Acyclovir is used for the treatment of herpes simplex virus infections, varicella zoster (chickenpox) and herpes zoster (shingles). Acyclovir has also been investigated for the treatment of herpes labialis applied using an iontophoretic device. Currently approved drugs for the treatment of herpes labialis (cold sores) exhibit low levels of efficacy due to the limited ability of the drugs to penetrate the skin to the site where the herpes virus is replicating. Iontophoresis uses electric current to enhance the delivery of drugs through the skin.

Acyclovir mechanism of action

Viral (HSV-1, HSV-2 and VZV) thymidine kinase converts Acyclovir to the Acyclovir monophosphate, which is then converted to the diphosphate by cellular guanylate kinase, and finally to the triphosphate by phosphoglycerate kinase, phosphoenolpyruvate carboxykinase, and pyruvate kinase. Acyclovir triphosphate competitively inhibits viral DNA polymerase and competes with the natural deoxyguanosine triphosphate, for incorporation into viral DNA. Once incorporated, Acyclovir triphosphate inhibits DNA synthesis by acting as a chain terminator. One may consider Acyclovir to be a prodrug as it is metabolized to more active compounds. Acyclovir is selective and low in cytotoxicity as the cellular thymidine kinase of normal, uninfected cells does not use Acyclovir effectively as a substrate.

Dosage forms of Acyclovir

FormRouteStrength
Capsuleoral200 mg/1
Capsuleoral400 mg/1
Injection, powder, lyophilized, for solutionintravenous1 g/1

Prescription Generics

true

International Brands

Acyclovir

Synonyms

Acyclovirum Acycloguanosine

Manufacturers

Red Pharm Drug Inc.

CAS number

59277-89-3

UNII

X4HES1O11F

State

solid

Affected organisms

Human Herpes Virus

Indication of Acyclovir

For the treatment and management of herpes zoster (shingles), genital herpes, and chickenpox.

Toxicity of Acyclovir

Acyclovir may cause nephrotoxicity (crystallization of Acyclovir within renal tubules, elevation of serum creatinine, transient), and neurotoxicity (coma, hallucinations, lethargy, seizures, tremors). Nephrotoxicity and neurotoxicity usually resolve after cessation of Acyclovir therapy. However, there is no well-defined relationship between Acyclovir concentrations in the blood and these adverse effects.

RX24 Drugs Disclaimer: consult your healthcare provider before buying a Acyclovir on prescription or using an RX manufacturer savings coupon. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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