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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Soriatane

$1,313.2430 capsules/10mg
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Acitretin volume of distribution

The acetylenic retinoates were hydrolyzed to their corresponding free acids at a much faster rate than etretinate in both animal species. All retinoates showed faster body clearance and larger volume of distribution than their free acids. In the obese rats, longer elimination half-lives and slower body clearance of the retinoids, except isotretinoin, were observed as compared to those in the normal rats. These results suggest that body fat has a significant effect on drug disposition and slows down the systemic clearance of retinoids.

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2018 Statistics

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Discount Cards 16,000+

benefit

Clients Benefit 29%

savings

Total savings $4,735,080

What is Acitretin

An oral retinoid effective in the treatment of psoriasis. It is the major metabolite of etretinate with the advantage of a much shorter half-life when compared with etretinate.

Acitretin mechanism of action

The mechanism of action of acitretin is unknown, however it is believed to work by targeting specific receptors (retinoid receptors such as RXR and RAR) in the skin which help normalize the growth cycle of skin cells.

Dosage forms of Acitretin

FormRouteStrength
Capsuleoral10 mg/1
Capsuleoral17.5 mg/1
Capsuleoral22.5 mg/1

Prescription Generics

true

International Brands

Acitretin

Synonyms

(all-e)-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid Acetretin

Manufacturers

Mylan Pharmaceuticals Inc.

CAS number

55079-83-9

UNII

LCH760E9T7

State

solid

Affected organisms

Humans and other mammals

Indication of Acitretin

For the treatment of severe psoriasis in adults.

Toxicity of Acitretin

Oral, rat: LD sub50 /sub = 4000 mg/kg. Symptoms of overdose include headache and vertigo.

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