Save up -80% on Adapalene
Note: this is a drug discount program, not an insurance plan.
2018 Price of Adapalene
Differin 0.1% cream
* price without discount in nearest pharmacy. Price may vary.
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Adapalene volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Adapalene
Adapalene is a topical retinoid primarily used in the treatment of acne and is also used (off-label) to treat keratosis pilaris as well as other skin conditions. It is currently marketed by Galderma under the trade names Differin in some countries, and Adaferin in India. (Wikipedia)
Adapalene mechanism of action
Mechanistically, adapalene binds to specific retinoic acid nuclear receptors (gamma and beta) and retinoid X receptors but does not bind to the cytosolic receptor protein. Although the exact mode of action of adapalene is unknown, it is suggested that topical adapalene may normalize the differentiation of follicular epithelial cells resulting in decreased microcomedone formation.
Dosage forms of Adapalene
6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acid Adaferin
Pru Gen, Inc.
Humans and other mammals
Indication of Adapalene
For the topical treatment of comedo, papular and pustular acne (acne vulgaris) of the face, chest or back.
Toxicity of Adapalene
The acute oral toxicity of adapalene in mice and rats is greater than 10 mL/kg. Chronic ingestion of the drug may lead to the same side effects as those associated with excessive oral intake of Vitamin A.
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