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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Differin

$92.851 gel pump (45g) 0.3%
Price with discount in nearest pharmacy. Price may vary.

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We offer free Differin coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Adapalene every time. What are you waiting for? Claim your prescription drug card now!

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Adapalene volume of distribution

The distribution and metabolism of absorbed adapalene is unknown. Excretion appears to be primarily by the biliary route.

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2018 Statistics

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Discount Cards 16,000+


Clients Benefit 29%


Total savings $4,735,080

What is Adapalene

Adapalene is a topical retinoid primarily used in the treatment of acne and is also used (off-label) to treat keratosis pilaris as well as other skin conditions. It is currently marketed by Galderma under the trade names Differin in some countries, and Adaferin in India. (Wikipedia)

Adapalene mechanism of action

Mechanistically, adapalene binds to specific retinoic acid nuclear receptors (gamma and beta) and retinoid X receptors but does not bind to the cytosolic receptor protein. Although the exact mode of action of adapalene is unknown, it is suggested that topical adapalene may normalize the differentiation of follicular epithelial cells resulting in decreased microcomedone formation.

Dosage forms of Adapalene

Differin Gel0.10%30g Gel$35.00
Differin Gel0.30%60g Gel$164.00
Adapalene0.10%45g Gel$41.00
Epiduo Gel0.1/2.5%45g Gel$137.00

Prescription Generics


International Brands



6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acid Adaferin


Pru Gen, Inc.

CAS number






Affected organisms

Humans and other mammals

Indication of Adapalene

For the topical treatment of comedo, papular and pustular acne (acne vulgaris) of the face, chest or back.

Toxicity of Adapalene

The acute oral toxicity of adapalene in mice and rats is greater than 10 mL/kg. Chronic ingestion of the drug may lead to the same side effects as those associated with excessive oral intake of Vitamin A.

RX24 Drugs Disclaimer: consult your healthcare provider before buying a Adapalene on prescription or using an RX manufacturer savings coupon. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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What is Differin?

Differin is a topical medication (a medicine applied to the surface of the skin), similar to vitamin A. It helps the skin to be renewed. Differin is used to treat severe acne in people who are at least 12 years old. It works by reducing the formation of acne.

Avoid getting Differin in the eyes, in the crease of the nose, or on the lips. If it gets into any of these areas, rinse with water. Do not use this medicine on tanned, windy, dry, cracked, irritated, or broken skin. Also avoid using this drug in wounds or on eczema patches. Wait until these conditions are healed before using Differin.

Do not use skin products containing alpha-hydroxy or glycolic acid while you are also using Differin.

Avoid skin products that may cause irritation, such as harsh soaps, shampoos or skin cleansers, hair dye or permanent chemicals, hair removers or waxes or skin products with alcohol, spices, astringents or lime. Do not use other skin treatments unless your doctor has told you so.

Avoid exposure to sunlight or artificial UV rays (sunglasses or tanning beds). Differin can make your skin more sensitive to sunlight and sunburn. Use sunscreen (minimum SPF 15) and wear protective clothing if you must be in the sun.