Save up -80% on Adefovir Dipivoxil
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Adefovir Dipivoxil
Hepsera 10 mg tablet
|price without discount in nearest pharmacy. Price may vary.|
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Adefovir Dipivoxil volume of distribution
* 392 75 mL/kg (Vd at steady state, intravenous administration of 1.0 mg/kg/day) * 352 9 mL/kg (Vd at steady state, intravenous administration of 3.0 mg/kg/day)
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Adefovir Dipivoxil
Adefovir dipivoxil, previously called bis-POM PMEA, with trade names Preveon and Hepsera, is an orally-administered acyclic nucleotide analog reverse transcriptase inhibitor (ntRTI) used for treatment of hepatitis B. It is ineffective against HIV-1. Adefovir dipivoxil is the diester prodrug of adefovir.
Adefovir Dipivoxil mechanism of action
Adefovir dipivoxil is a prodrug of adefovir. Adefovir is an acyclic nucleotide analog of adenosine monophosphate which is phosphorylated to the active metabolite adefovir diphosphate by cellular kinases. Adefovir diphosphate inhibits HBV DNA polymerase (reverse transcriptase) by competing with the natural substrate deoxyadenosine triphosphate and by causing DNA chain termination after its incorporation into viral DNA. The inhibition constant (Ki) for adefovir diphosphate for HBV DNA polymerase was 0.1 mu;M. Adefovir diphosphate is a weak inhibitor of human DNA polymerases alpha; and gamma; with Ki values of 1.18 mu;M and 0.97mu;M, respectively.
Dosage forms of Adefovir Dipivoxil
|Tablet||Oral use||10 mg|
Sigmapharm Laboratories, LLC
Hepatitis B virus
Indication of Adefovir Dipivoxil
For the treatment of chronic hepatitis B in adults with evidence of active viral replication and either evidence of persistent elevations in serum aminotransferases (ALT or AST) or histologically active disease.
Toxicity of Adefovir Dipivoxil
Renal tubular nephropathy characterized by histological alterations and/or increases in BUN and serum creatinine was the primary dose-limiting toxicity associated with administration of adefovir dipivoxil in animals. Nephrotoxicity was observed in animals at systemic exposures approximately 3ndash;10 times higher than those in humans at the recommended therapeutic dose of 10 mg/day.
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