Save up -80% on Adefovir Dipivoxil
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Hepsera
|$1,409.26||1 bottle (30 tablets) 10mg|
|price without discount in nearest pharmacy. Price may vary.|
We offer free Hepsera coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Adefovir Dipivoxil every time. What are you waiting for? Claim your prescription drug card now!
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Adefovir Dipivoxil volume of distribution
The approximate oral bioavailability of adefovir from HEPSERA is 59%. When a single oral 10 mg dose is given to chronic hepatitis B patients, the peak plasma concentration (Cmax) of adefovir was 18.4 ± 6.26 ng/mL. This occurred between 0.58 – 4 hours post dose (Tmax).
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Adefovir Dipivoxil
Adefovir dipivoxil, previously called bis-POM PMEA, with trade names Preveon and Hepsera, is an orally-administered acyclic nucleotide analog reverse transcriptase inhibitor (ntRTI) used for treatment of hepatitis B. It is ineffective against HIV-1. Adefovir dipivoxil is the diester prodrug of adefovir.
Adefovir Dipivoxil mechanism of action
Adefovir dipivoxil is a prodrug of adefovir. Adefovir is an acyclic nucleotide analog of adenosine monophosphate which is phosphorylated to the active metabolite adefovir diphosphate by cellular kinases. Adefovir diphosphate inhibits HBV DNA polymerase (reverse transcriptase) by competing with the natural substrate deoxyadenosine triphosphate and by causing DNA chain termination after its incorporation into viral DNA. The inhibition constant (Ki) for adefovir diphosphate for HBV DNA polymerase was 0.1 mu;M. Adefovir diphosphate is a weak inhibitor of human DNA polymerases alpha; and gamma; with Ki values of 1.18 mu;M and 0.97mu;M, respectively.
Dosage forms of Adefovir Dipivoxil
|Tablet||Oral use||10 mg|
Sigmapharm Laboratories, LLC
Hepatitis B virus
Indication of Adefovir Dipivoxil
For the treatment of chronic hepatitis B in adults with evidence of active viral replication and either evidence of persistent elevations in serum aminotransferases (ALT or AST) or histologically active disease.
Toxicity of Adefovir Dipivoxil
Renal tubular nephropathy characterized by histological alterations and/or increases in BUN and serum creatinine was the primary dose-limiting toxicity associated with administration of adefovir dipivoxil in animals. Nephrotoxicity was observed in animals at systemic exposures approximately 3ndash;10 times higher than those in humans at the recommended therapeutic dose of 10 mg/day.
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