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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Adefovir Dipivoxil

Hepsera 10 mg tablet

$30.32

tablet

* price without discount in nearest pharmacy. Price may vary.

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Adefovir Dipivoxil volume of distribution

* 392 75 mL/kg (Vd at steady state, intravenous administration of 1.0 mg/kg/day) * 352 9 mL/kg (Vd at steady state, intravenous administration of 3.0 mg/kg/day)

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What is Adefovir Dipivoxil

Adefovir dipivoxil, previously called bis-POM PMEA, with trade names Preveon and Hepsera, is an orally-administered acyclic nucleotide analog reverse transcriptase inhibitor (ntRTI) used for treatment of hepatitis B. It is ineffective against HIV-1. Adefovir dipivoxil is the diester prodrug of adefovir.

Adefovir Dipivoxil mechanism of action

Adefovir dipivoxil is a prodrug of adefovir. Adefovir is an acyclic nucleotide analog of adenosine monophosphate which is phosphorylated to the active metabolite adefovir diphosphate by cellular kinases. Adefovir diphosphate inhibits HBV DNA polymerase (reverse transcriptase) by competing with the natural substrate deoxyadenosine triphosphate and by causing DNA chain termination after its incorporation into viral DNA. The inhibition constant (Ki) for adefovir diphosphate for HBV DNA polymerase was 0.1 mu;M. Adefovir diphosphate is a weak inhibitor of human DNA polymerases alpha; and gamma; with Ki values of 1.18 mu;M and 0.97mu;M, respectively.

Dosage forms of Adefovir Dipivoxil

FormRouteStrength
Tabletoral10 mg/1
Tabletoral10 mg
TabletOral use10 mg
Prescription Generics

true

International Brands

Adefovir Dipivoxil

Synonyms

Adefovir Adefovir

Manufacturers

Sigmapharm Laboratories, LLC

CAS number

142340-99-6

UNII

U6Q8Z01514

State

solid

Affected organisms

Hepatitis B virus

Indication of Adefovir Dipivoxil

For the treatment of chronic hepatitis B in adults with evidence of active viral replication and either evidence of persistent elevations in serum aminotransferases (ALT or AST) or histologically active disease.

Toxicity of Adefovir Dipivoxil

Renal tubular nephropathy characterized by histological alterations and/or increases in BUN and serum creatinine was the primary dose-limiting toxicity associated with administration of adefovir dipivoxil in animals. Nephrotoxicity was observed in animals at systemic exposures approximately 3ndash;10 times higher than those in humans at the recommended therapeutic dose of 10 mg/day.

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