Save up -80% on Afatinib

Note: this is a drug discount program, not an insurance plan.

RX BIN: 015558
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Afatinib


* price without discount in nearest pharmacy. Price may vary.

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Afatinib volume of distribution

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What is Afatinib

Afatinib is a tyrosine kinase inhibitor which is a 4-anilinoquinazoline. It is prepared has the dimaleate salt. FDA approved on July 12, 2013.

Afatinib mechanism of action

Afatinib is an irreversible kinase inhibitor and binds to the kinase domains of EGFR (ErbB1), HER2 (ErbB2), and HER4 (ErbB4) to inhibit tyrosine kinase autophosphorylation. This results in a downregulation of ErbB signalling and subsequent inhibition of proliferation of cell lines expressing wild-type EGFR, selected EGFR exon 19 deletion mutations, or exon 21 L858R mutations. It also inhibited in vitro proliferation of cell lines overexpressing HER2. Overall, tumour growth was inhibited.

Dosage forms of Afatinib

Form Route Strength
Tablet, film coated oral 20 mg/1
Tablet, film coated oral 30 mg/1
Tablet, film coated oral 40 mg/1
Prescription Generics


International Brands



Afatinibum BIBW 2992


Boehringer Ingelheim Pharmaceuticals, Inc.

CAS number






Affected organisms

Humans and other mammals

Indication of Afatinib

Afatinib is a kinase inhibitor indicated for the first-line treatment of patient with metastatic non-small cell lung cancer (NSCLC) whose tumours have epidermal growth factor receptor (EGFR) exon 19 deletions or exon 21 (L858R) substitution mutations as detected by an FDA-approved test.

Toxicity of Afatinib

Most common adverse reactions ( 20%) are diarrhea, rash/dermatitis, acneiform, stomatitis, paronychia, dry skin, decreased appetite, pruritus.

RX24 Drugs Disclaimer: before buying a Afatinib on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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