Save up -80% on Afatinib

Note: this is a drug discount program, not an insurance plan.
RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Gilotrif

$8,82430 tablets/20 mg
price without discount in nearest pharmacy. Price may vary.

Claim your free Afatinib discount card

We offer free Afatinib coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Afatinib every time. What are you waiting for? Claim your prescription drug card now!

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Afatinib volume of distribution

The volume of distribution of afatinib recorded in healthy male volunteers is documented as 4500 L. Such a high volume of distribution in plasma suggests a potentially high tissue distribution. In vitro binding of afatinib to human plasma proteins is approximately 95%.

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About RX24Drugs

2018 Statistics

discount card

Discount Cards 16,000+

benefit

Clients Benefit 29%

savings

Total savings $4,735,080

What is Afatinib

Afatinib is a tyrosine kinase inhibitor which is a 4-anilinoquinazoline. It is prepared has the dimaleate salt. FDA approved on July 12, 2013.

Afatinib mechanism of action

Afatinib is an irreversible kinase inhibitor and binds to the kinase domains of EGFR (ErbB1), HER2 (ErbB2), and HER4 (ErbB4) to inhibit tyrosine kinase autophosphorylation. This results in a downregulation of ErbB signalling and subsequent inhibition of proliferation of cell lines expressing wild-type EGFR, selected EGFR exon 19 deletion mutations, or exon 21 L858R mutations. It also inhibited in vitro proliferation of cell lines overexpressing HER2. Overall, tumour growth was inhibited.

Dosage forms of Afatinib

DrugDosageQuantityPrice
Gilotrif20mg30 tabletes$8,326
Gilotrif30mg18 tabletes$5,000
Gilotrif40mg15 tabletes$4,168

Prescription Generics

false

International Brands

Gilotrif

Synonyms

Afatinibum BIBW 2992

Manufacturers

Boehringer Ingelheim Pharmaceuticals, Inc.

CAS number

850140-72-6

UNII

41UD74L59M

State

solid

Affected organisms

Humans and other mammals

Indication of Afatinib

Afatinib is a kinase inhibitor indicated for the first-line treatment of patient with metastatic non-small cell lung cancer (NSCLC) whose tumours have epidermal growth factor receptor (EGFR) exon 19 deletions or exon 21 (L858R) substitution mutations as detected by an FDA-approved test.

Toxicity of Afatinib

Most common adverse reactions ( 20%) are diarrhea, rash/dermatitis, acneiform, stomatitis, paronychia, dry skin, decreased appetite, pruritus.

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