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Price of Albendazole
Albenza 200 mg tablet
* price without discount in nearest pharmacy. Price may vary.
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Albendazole volume of distribution
What is Albendazole
A benzimidazole broad-spectrum anthelmintic structurally related to mebendazole that is effective against many diseases. (From Martindale, The Extra Pharmacopoeia, 30th ed, p38)
Albendazole mechanism of action
Albendazole causes degenerative alterations in the tegument and intestinal cells of the worm by binding to the colchicine-sensitive site of tubulin, thus inhibiting its polymerization or assembly into microtubules. The loss of the cytoplasmic microtubules leads to impaired uptake of glucose by the larval and adult stages of the susceptible parasites, and depletes their glycogen stores. Degenerative changes in the endoplasmic reticulum, the mitochondria of the germinal layer, and the subsequent release of lysosomes result in decreased production of adenosine triphosphate (ATP), which is the energy required for the survival of the helminth. Due to diminished energy production, the parasite is immobilized and eventually dies.
Dosage forms of Albendazole
|Tablet, film coated||oral||200 mg/1|
(5-(Propylthio)-1H-benzimidazol-2-yl)carbamic acid methyl ester
Amedra Pharmaceuticals LLC
Indication of Albendazole
For the treatment of parenchymal neurocysticercosis due to active lesions caused by larval forms of the pork tapeworm, iTaenia solium /i and for the treatment of cystic hydatid disease of the liver, lung, and peritoneum, caused by the larval form of the dog tapeworm, iEchinococcus granulosus /i.
Toxicity of Albendazole
Symptoms of overdose include elevated liver enzymes, headaches, hair loss, low levels of white blood cells (neutropenia), fever, and itching.
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