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Price of Alclometasone
Alclometasone dipro 0.05% crm
* price without discount in nearest pharmacy. Price may vary.
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Alclometasone volume of distribution
What is Alclometasone
Alclometasone is synthetic glucocorticoid steroid for topical use in dermatology as anti-inflammatory, antipruritic, antiallergic, antiproliferative and vasoconstrictive agent. (Wikipedia)
Alclometasone mechanism of action
The mechanism of the anti-inflammatory activity of the topical steroids, in general, is unclear. However, corticosteroids are thought to act by the induction of phospholipase A sub 2 /sub inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A sub 2 /sub . Alclometasone initially binds the corticosteroid receptor. This complex migrates to the nucleus where it binds to different glucocorticoid response elements on the DNA. This in turn enhances and represses various genes, especially those involved in inflammatory pathways.
Dosage forms of Alclometasone
PharmaDerm, A division of Nycomed US Inc.
Humans and other mammals
Indication of Alclometasone
For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.
Toxicity of Alclometasone
Symptoms of overdose include suppression of adrenal glands, temporary decrease in white blood cell counts, symptoms of hypersensitivity (such as skin rash, hives, itching, and difficulty breathing), and increased susceptibility to infection.
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