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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Alclometasone

Alclometasone dipro 0.05% crm

$1.21

g

* price without discount in nearest pharmacy. Price may vary.

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Alclometasone volume of distribution

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What is Alclometasone

Alclometasone is synthetic glucocorticoid steroid for topical use in dermatology as anti-inflammatory, antipruritic, antiallergic, antiproliferative and vasoconstrictive agent. (Wikipedia)

Alclometasone mechanism of action

The mechanism of the anti-inflammatory activity of the topical steroids, in general, is unclear. However, corticosteroids are thought to act by the induction of phospholipase A sub 2 /sub inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A sub 2 /sub . Alclometasone initially binds the corticosteroid receptor. This complex migrates to the nucleus where it binds to different glucocorticoid response elements on the DNA. This in turn enhances and represses various genes, especially those involved in inflammatory pathways.

Dosage forms of Alclometasone

FormRouteStrength
Creamtopical.5 mg/g
Ointmenttopical.5 mg/g
Prescription Generics

true

International Brands

Aclovate

Synonyms

(7alpha,11beta,16alpha)-7-chloro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione 7-Chloro-16-methylprednisolone

Manufacturers

PharmaDerm, A division of Nycomed US Inc.

CAS number

67452-97-5

UNII

136H45TB7B

State

solid

Affected organisms

Humans and other mammals

Indication of Alclometasone

For the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.

Toxicity of Alclometasone

Symptoms of overdose include suppression of adrenal glands, temporary decrease in white blood cell counts, symptoms of hypersensitivity (such as skin rash, hives, itching, and difficulty breathing), and increased susceptibility to infection.

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