Save up -80% on Aldesleukin
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Proleukin
|price without discount in nearest pharmacy. Price may vary.|
We offer free Proleukin coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Aldesleukin every time. What are you waiting for? Claim your prescription drug card now!
Get your Prescription
It’s safe and free
Buy drugs in pharmacy
Save money each time
Aldesleukin volume of distribution
Greater than 80% of the amount of Proleukin distributed to plasma, cleared from the circulation and presented to the kidney is metabolized to amino acids in the cells lining the proximal convoluted tubules. In humans, the mean clearance rate in cancer patients is 268 mL/min.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Aldesleukin
Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This recombinant form differs from native interleukin-2 in the following ways: a) Aldesleukin is not glycosylated because it is derived from E. coli; b) the molecule has no N-terminal alanine; the codon for this amino acid was deleted during the genetic engineering procedure; c) the molecule has serine substituted for cysteine at amino acid position 125.
Aldesleukin mechanism of action
Aldesleukin binds to the IL-2 receptor which leads to heterodimerization of the cytoplasmic domains of the IL-2R beta and gamma(c) chains, activation of the tyrosine kinase Jak3, and phosphorylation of tyrosine residues on the IL-2R beta chain. These events led to the creation of an activated receptor complex, to which various cytoplasmic signaling molecules are recruited and become substrates for regulatory enzymes (especially tyrosine kinases) that are associated with the receptor. These events stimulate growth and differentiation of T cells.
Dosage forms of Aldesleukin
|Injection, powder, lyophilized, for solution||intravenous||1.1 mg/mL|
|Powder for solution||intravenous||22000000 unit|
125-L-serine-2-133-interleukin 2 (human reduced) Interleukin-2 aldesleukin
Prometheus Laboratories Inc.
Humans and other mammals
Indication of Aldesleukin
For treatment of adults with metastatic renal cell carcinoma.
Toxicity of Aldesleukin
In multiple phase 2 and 3 clinical trials, interleukin-2 was found to cause mild-to-moderate serum enzyme elevations in at least half of patients receiving intravenous therapy for malignancies. These elevations were generally transient and without obvious symptoms of liver injury, but rose to levels above 5 to 10 times ULN and necessitated early discontinuation or delay in further therapy in some patients.
RX24 Drugs Disclaimer: consult your healthcare provider before buying a Aldesleukin on prescription or using an RX manufacturer savings coupon. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.