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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Aldesleukin

Proleukin 22000000 unit Solution Vial

$976.66

vial

* price without discount in nearest pharmacy. Price may vary.

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Aldesleukin volume of distribution

0.18 l/kg

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What is Aldesleukin

Aldesleukin, a lymphokine, is produced by recombinant DNA technology using a genetically engineered E. coli strain containing an analog of the human interleukin-2 gene. Genetic engineering techniques were used to modify the human IL-2 gene, and the resulting expression clone encodes a modified human interleukin-2. This recombinant form differs from native interleukin-2 in the following ways: a) Aldesleukin is not glycosylated because it is derived from E. coli; b) the molecule has no N-terminal alanine; the codon for this amino acid was deleted during the genetic engineering procedure; c) the molecule has serine substituted for cysteine at amino acid position 125.

Aldesleukin mechanism of action

Aldesleukin binds to the IL-2 receptor which leads to heterodimerization of the cytoplasmic domains of the IL-2R beta and gamma(c) chains, activation of the tyrosine kinase Jak3, and phosphorylation of tyrosine residues on the IL-2R beta chain. These events led to the creation of an activated receptor complex, to which various cytoplasmic signaling molecules are recruited and become substrates for regulatory enzymes (especially tyrosine kinases) that are associated with the receptor. These events stimulate growth and differentiation of T cells.

Dosage forms of Aldesleukin

FormRouteStrength
Injectionintravenous1.1 mg/mL
Injection, powder, lyophilized, for solutionintravenous1.1 mg/mL
Powder for solutionintravenous22000000 unit
Prescription Generics

false

International Brands

Proleukin

Synonyms

125-L-serine-2-133-interleukin 2 (human reduced) Interleukin-2 aldesleukin

Manufacturers

Prometheus Laboratories Inc.

CAS number

110942-02-4

UNII

M89N0Q7EQR

State

liquid

Affected organisms

Humans and other mammals

Indication of Aldesleukin

For treatment of adults with metastatic renal cell carcinoma.

Toxicity of Aldesleukin

RX24 Drugs Disclaimer: before buying a Aldesleukin on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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