Save up -80% on Alendronic acid

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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Alendronic acid

Alendronate sodium 10 mg tablet

$2.99tablet
price without discount in nearest pharmacy. Price may vary.

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We offer free Alendronic acid coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Alendronic acid every time. What are you waiting for? Claim your prescription drug card now!

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Alendronic acid volume of distribution

* 28 L

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About RX24Drugs

2018 Statistics

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Discount Cards 16,000+

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Clients Benefit 29%

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Total savings $4,735,080

What is Alendronic acid

Alendronic acid (alendronate) is a nitrogen-containing, second generation bisphosphonate. Bisphosphonates were first used to treat Pagets disease in 1971. This class of medications is comprised of inorganic pyrophosphate analogues that contain non-hydrolyzable P-C-P bonds. Similar to other bisphosphonates, alendronate has a high affinity for bone mineral and is taken up during osteoclast resorption. Alendronate inhibits farnesyl pyrophosphate synthetase, one of the enzymes in the mevalonic acid pathway involved in producing isoprenoid compounds that are essential for post-translational modification of small guanosine triphosphate (GTP)-binding proteins, such as Rho, Ras and Rab. Inhibition of this process interferes with osteoclast function and survival. Alendronate is used for the treatment of osteoporosis and Pagets disease.

Alendronic acid mechanism of action

The action of Alendronate on bone tissue is based partly on its affinity for hydroxyapatite, which is part of the mineral matrix of bone. Alendronate also targets farnesyl pyrophosphate (FPP) synthase. Nitrogen-containing bisphosphonates (such as pamidronate, alendronate, risedronate, ibandronate and zoledronate) appear to act as analogues of isoprenoid diphosphate lipids, thereby inhibiting FPP synthase, an enzyme in the mevalonate pathway. Inhibition of this enzyme in osteoclasts prevents the biosynthesis of isoprenoid lipids (FPP and GGPP) that are essential for the post-translational farnesylation and geranylgeranylation of small GTPase signalling proteins. This activity inhibits osteoclast activity and reduces bone resorption and turnover. In postmenopausal women, it reduces the elevated rate of bone turnover, leading to, on average, a net gain in bone mass.

Dosage forms of Alendronic acid

FormRouteStrength
TabletOral use
Solutionoral70 mg/75mL
Tabletoral10 mg/1

Prescription Generics

false

International Brands

Accel-alendronate

Synonyms

(4-amino-1-hydroxybutane-1,1-diyl)bis(phosphonic acid) (4-amino-1-hydroxybutylidene)bisphosphonic acid

Manufacturers

Accel Pharma Inc

CAS number

66376-36-1

UNII

X1J18R4W8P

State

solid

Affected organisms

Humans and other mammals

Indication of Alendronic acid

For the treatment and prevention of osteoporosis in women and Paget’s disease of bone in both men and women.

Toxicity of Alendronic acid

Alendronate can damage the esophagus both by toxicity from the medication itself and by nonspecific irritation secondary to contact between the pill and the esophageal mucosa, similar to other cases of “pill esophagitis.”

RX24 Drugs Disclaimer: consult your healthcare provider before buying a Alendronic acid on prescription or using an RX manufacturer savings coupon. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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