Save up -80% on Alglucosidase alfa
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
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2019 Price of Alglucosidase alfa
Myozyme 50 mg vial
|price without discount in nearest pharmacy. Price may vary.|
We offer free Alglucosidase alfa coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your discount card in most local pharmacies to get a discount on Alglucosidase alfa every time. What are you waiting for? Claim your prescription drug card now!
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Alglucosidase alfa volume of distribution
* 96 16 mL/kg (20 mg/kg dose) * 119 28 mL/kg (40 mg/kg dose)
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Alglucosidase alfa
Aglucosidase alfa consists of the human enzyme acid alpha-glucosidase (GAA) which is essential for the degradation of glygogen to glucose in lysosomes. It is encoded by the most predominant of nine observed haplotypes of this gene. Aglucosidase alfa is produced by recombinant DNA technology in a Chinese hamster ovary cell line. Alglucosidase alfa degrades glycogen by catalyzing the hydrolysis of a-1,4- and a-1,6- glycosidic linkages of lysosomal glycogen. Structurally, Alglucosidase alfa is a glycoprotein with a calculated mass of 98,008 daltons for the 883 residue mature polypeptide chain, and a total mass of approximately 109,000 daltons, including carbohydrates. It is used for the treatment of Pompe disease (GAA deficiency) in infants and pediatric patients.
Alglucosidase alfa mechanism of action
Alglucosidase alfa is designed to act as an exogenous source of GAA, acting to correct GAA deficiency that is the hallmark of Pompe disease. Alglucosidase alfa binds to mannose-6-phosphate receptors on the cell surface via carbohydrate groups on the GAA molecule, after which it is internalized and transported into lysosomes, where it undergoes proteolytic cleavage that results in increased enzymatic activity. It then exerts enzymatic activity in cleaving glycogen. Specifically, it hydrolyses alpha-1,4-glucose bonds.
Dosage forms of Alglucosidase alfa
|Injection, powder, for solution||intravenous||5 mg/mL|
|Injection, powder, lyophilized, for solution||intravenous||5 mg/mL|
|Powder for concentrate for solution for infusion||Intravenous use||50 mg|
Acid maltase Acid-alpha glucosidase
Humans and other mammals
Indication of Alglucosidase alfa
For the treatment of Pompe disease (GAA deficiency) in infants and pediatric patients.
Toxicity of Alglucosidase alfa
There have been no reports of overdose with alglucosidase alfa.
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