Save up -80% on Alitretinoin

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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Panretin

$5,246.141 tube (60g) 0.1% gel
Price with discount in nearest pharmacy. Price may vary.

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Alitretinoin volume of distribution

The highest level of alitretinoin in semen was 7.92 ng/mL. Assuming an ejaculate volume of 10 mL, the amount of drug transferred in semen would be about 80 ng, 1/375,000 of a single 30 mg capsule. Complete absorption of 80 ng of alitretinoin from semen, presuming a volume of distribution confined to 5 L of circulating blood in the partner, would lead to an increase in plasma alitretinoin concentration of 0.016 ng/mL, which appears to be negligible compared with measured endogenous plasma levels. Increases in plasma levels of related retinoids are also negligible.

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2018 Statistics

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Discount Cards 16,000+

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Clients Benefit 29%

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Total savings $4,735,080

What is Alitretinoin

An important regulator of gene expression during growth and development, and in neoplasms. Tretinoin, also known as retinoic acid and derived from maternal vitamin A, is essential for normal growth; and embryonic development. An excess of tretinoin can be teratogenic. It is used in the treatment of psoriasis; acne vulgaris; and several other skin diseases. It has also been approved for use in promyelocytic leukemia (leukemia, promyelocytic, acute).

Alitretinoin mechanism of action

Alitretinoin binds to and activates all known intracellular retinoid receptor subtypes (RARa, RARb, RARg, RXRa, RXRb and RXRg). Once activated these receptors function as transcription factors that regulate the expression of genes that control the process of cellular differentiation and proliferation in both normal and neoplastic cells.

Dosage forms of Alitretinoin

FormRouteStrength
GelCutaneous use0.1 %
Geltopical0.1 %
Geltopical60 mg/60g

Prescription Generics

false

International Brands

Panretin

Synonyms

(2e,4e,6Z,8e)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid (7e,9Z,11e,13e)-Retinoic acid

Manufacturers

Eisai Inc.

CAS number

5300-03-8

UNII

1UA8E65KDZ

State

solid

Affected organisms

Humans and other mammals

Indication of Alitretinoin

For topical treatment of cutaneous lesions in patients with AIDS-related Kaposi’s sarcoma.

Toxicity of Alitretinoin

In the Japanese flounder Paralichthys olivaceus, at 6-9 days post-hatching, all retinoic acid isomers (including alitretinoin) exerted toxic effects on the skeletal systems, mainly through the RAR pathway.

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