Save up -80% on Allopurinol
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Price of Allopurinol
Zyloprim 300 mg tablet
* price without discount in nearest pharmacy. Price may vary.
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Allopurinol volume of distribution
What is Allopurinol
A xanthine oxidase inhibitor that decreases uric acid production. It also acts as an antimetabolite on some simpler organisms. (PubChem)
Allopurinol mechanism of action
Allopurinol and its active metabolite, oxypurinol, inhibits the enzyme xanthine oxidase, blocking the conversion of the oxypurines hypoxanthine and xanthine to uric acid. Elevated concentrations of oxypurine and oxypurine inhibition of xanthine oxidase through negative feedback results in a decrease in the concentrations of uric acid in the serum and urine. Allopurinol also facilitates the incorporation of hypoxanthine and xanthine into DNA and RNA, leading to a feedback inhibition of de novo purin synthesis and a decrease in serum uric acid concentrations as a result of an increase in nucleotide concentration.
Dosage forms of Allopurinol
Valeant Canada Lp Valeant Canada S.E.C.
Humans and other mammals
Indication of Allopurinol
For the treatment of hyperuricemia associated with primary or secondary gout. Also indicated for the treatment of primary or secondary uric acid nephropathy, with or without the symptoms of gout, as well as chemotherapy-induced hyperuricemia and recurrent renal calculi.
Toxicity of Allopurinol
LD sub50 /sub=214 mg/kg (in mice)
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