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RX BIN: 015558
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Allopurinol

Zyloprim 300 mg tablet



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Allopurinol volume of distribution

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What is Allopurinol

A xanthine oxidase inhibitor that decreases uric acid production. It also acts as an antimetabolite on some simpler organisms.

Allopurinol mechanism of action

Allopurinol and its active metabolite, oxypurinol, inhibits the enzyme xanthine oxidase, blocking the conversion of the oxypurines hypoxanthine and xanthine to uric acid. Elevated concentrations of oxypurine and oxypurine inhibition of xanthine oxidase through negative feedback results in a decrease in the concentrations of uric acid in the serum and urine. Allopurinol also facilitates the incorporation of hypoxanthine and xanthine into DNA and RNA, leading to a feedback inhibition of de novo purin synthesis and a decrease in serum uric acid concentrations as a result of an increase in nucleotide concentration.

Dosage forms of Allopurinol

Form Route Strength
Tablet oral 100 mg/1
Tablet oral 300 mg
Tablet oral 300 mg/1
Prescription Generics


International Brands



1,5-Dihydro-4H-pyrazolo(3,4-D)pyrimidin-4-one 1,5-Dihydro-4H-pyrazolo(3,4-D)pyrimidine-4-one


Valeant Canada Lp Valeant Canada S.E.C.

CAS number






Affected organisms

Humans and other mammals

Indication of Allopurinol

For the treatment of hyperuricemia associated with primary or secondary gout. Also indicated for the treatment of primary or secondary uric acid nephropathy, with or without the symptoms of gout, as well as chemotherapy-induced hyperuricemia and recurrent renal calculi.

Toxicity of Allopurinol

LD sub50 /sub=214 mg/kg (in mice)

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