Save up -80% on Alosetron
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2018 Price of Alosetron
Lotronex 0.5 mg tablet
* price without discount in nearest pharmacy. Price may vary.
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Alosetron volume of distribution
* 65 to 95 L
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Alosetron
Alosetron is a 5-HT3 antagonist used only for the management of severe diarrhoea-predominant irritable bowel syndrome (IBS) in women. Alosetron has an antagonist action on the 5-HT3 receptors and thus may modulate serotonin-sensitive gastrointestinal (GI) processes. Alosetron was voluntarily withdrawn from the US market in November 2000 by the manufacturer due to numerous reports of severe adverse effects including ischemic colitis, severely obstructed or ruptured bowel, and death. In June 2002, the FDA approved a supplemental new drug application allowing the remarketing of the drug under restricted conditions of use.
Alosetron mechanism of action
Alosetron is a potent and selective 5-HT sub 3 /sub receptor antagonist. 5-HT sub 3 /sub receptors are nonselective cation channels that are extensively distributed on enteric neurons in the human gastrointestinal tract, as well as other peripheral and central locations. Activation of these channels and the resulting neuronal depolarization affect the regulation of visceral pain, colonic transit and gastrointestinal secretions, processes that relate to the pathophysiology of irritable bowel syndrome (IBS). 5-HT sub 3 /sub receptor antagonists such as alosetron inhibit activation of non-selective cation channels which results in the modulation of serotonin-sensitive GI motor and sensory processes.
Dosage forms of Alosetron
West Ward Pharmaceuticals Corp.
Humans and other mammals
Indication of Alosetron
Only for the treatment of symptoms of severe diarrhea-predominant irritable bowel syndrome (IBS) in women with chronic symptoms (generally lasting greater than 6 months) who does not present with anatomic or biochemical GI abnormalities and have not responded to conventional therapy.
Toxicity of Alosetron
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