Save up -80% on Alpha-1-proteinase inhibitor
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Price of Alpha-1-proteinase inhibitor
Prolastin 1000 mg vial
* price without discount in nearest pharmacy. Price may vary.
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Alpha-1-proteinase inhibitor volume of distribution
* 5632 . 2006 mL [ARALAST NP] ;
* 5618 . 1618 mL [Aralast]
What is Alpha-1-proteinase inhibitor
Human alpha-1 proteinase inhibitor or alpha-1-antitrypsin, prepared from human plasma via Cohn alcohol fractionation followed by PEG and zinc chloride fractionation.
Alpha-1-proteinase inhibitor mechanism of action
Alpha-1 proteinase inhibitor is a serine protease inhibitor (Serpin). Its primary mechanism is inhibiting the action of the serine protease called elastase (also plasmin and thrombin) in the lungs. The reactive center loop (RCL) of alpha-1 proteinase inhibitor extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable.
Dosage forms of Alpha-1-proteinase inhibitor
|Injection, solution||intravenous||1 g/50mL|
Alpha 1-Proteinase Inhibitor
Baxalta Us Inc.
Humans and other mammals
Indication of Alpha-1-proteinase inhibitor
For chronic augmentation and maintenance therapy in individuals with alpha1-proteinase inhibitor (A1-PI) deficiency and clinical evidence of emphysema.
Toxicity of Alpha-1-proteinase inhibitor
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