Save up -80% on Alpha-1-proteinase inhibitor

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RX BIN: 015558
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Alpha-1-proteinase inhibitor

Prolastin 1000 mg vial



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Alpha-1-proteinase inhibitor volume of distribution

* 5632 . 2006 mL[ARALAST NP]; * 5618 . 1618 mL[Aralast]

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What is Alpha-1-proteinase inhibitor

Human alpha-1 proteinase inhibitor or alpha-1-antitrypsin, prepared from human plasma via Cohn alcohol fractionation followed by PEG and zinc chloride fractionation.

Alpha-1-proteinase inhibitor mechanism of action

Alpha-1 proteinase inhibitor is a serine protease inhibitor (Serpin). Its primary mechanism is inhibiting the action of the serine protease called elastase (also plasmin and thrombin) in the lungs. The reactive center loop (RCL) of alpha-1 proteinase inhibitor extends out from the body of the protein and directs binding to the target protease. The protease cleaves the serpin at the reactive site, establishing a covalent linkage between the carboxyl group of the serpin reactive site and the serine hydroxyl of the protease. The resulting inactive serpin-protease complex is highly stable.

Dosage forms of Alpha-1-proteinase inhibitor

Form Route Strength
Injection, solution intravenous 1 g/50mL
Prescription Generics


International Brands

Aralast Np


Alpha 1-antitrypsin Alpha 1-Proteinase Inhibitor


Baxalta Us Inc.

CAS number






Affected organisms

Humans and other mammals

Indication of Alpha-1-proteinase inhibitor

For chronic augmentation and maintenance therapy in individuals with alpha1-proteinase inhibitor (A1-PI) deficiency and clinical evidence of emphysema.

Toxicity of Alpha-1-proteinase inhibitor

RX24 Drugs Disclaimer: before buying a Alpha-1-proteinase inhibitor on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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