Save up -80% on Alprostadil
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Edex
|$175.39||1 package (2 cartridges) 20 mcg|
|price without discount in nearest pharmacy. Price may vary.|
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Alprostadil volume of distribution
The absolute bioavailability of alprostadil estimated from systemic exposure was about 98% as compared to the same dose given by a short-term intravenous infusion. Distribution: The volume of distribution for PGE1 was not estimated. Approximately 93% of PGE1 found in plasma is protein-bound.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Alprostadil
Alprostadil is produced endogenously and causes vasodilation by means of a direct effect on vascular and ductus arteriosus (DA) smooth muscle, preventing or reversing the functional closure of the DA that occurs shortly after birth. This results in increased pulmonary or systemic blood flow in infants. In infants, it is used for palliative, not definitive, therapy to temporarily maintain the patency of the ductus arteriosus until corrective or palliative surgery can be performed in neonates who have congenital heart defects and who depend upon the patent ductus for survival. In adults, it is used for the treatment of erectile dysfunction due to neurogenic, vasculogenic, psychogenic, or mixed etiology.
Alprostadil mechanism of action
Alprostadil causes vasodilation by means of a direct effect on vascular and ductus arteriosus (DA) smooth muscle, preventing or reversing the functional closure of the DA that occurs shortly after birth. This is because, as a form of prostaglandinE1 (PGE1) it has multiple effects on blood flow. This results in increased pulmonary or systemic blood flow in infants. In cyanotic congenital heart disease, alprostadil’s actions result in an increased oxygen supply to the tissues. In infants with interrupted aortic arch or very severe aortic coarctation, alprostadil maintains distal aortic perfusion by permitting blood flow through the DA from the pulmonary artery to the aorta. In infants with aortic coarctation, alprostadil reduces aortic obstruction either by relaxing ductus tissue in the aortic wall or by increasing effective aortic diameter by dilating the DA. In infants with these aortic arch anomalies, systemic blood flow to the lower body is increased, improving tissue oxygen supply and renal perfusion. When administered by intracavernosal injection or as an intraurethral suppository, alprostadil acts locally to relax the trabecular smooth muscle of the corpora cavernosa and the cavernosal arteries. Swelling, elongation, and rigidity of the penis result when arterial blood rapidly flows into the corpus cavernosum to expand the lacunar spaces. The entrapped blood reduces the venous blood outflow as sinusoids compress against the tunica albuginea.
Dosage forms of Alprostadil
|Caverject Kit||20mcg||5vials Solution for Injection||$170.00|
|Caverject Kit||20mcg||10vials Solution for Injection||$306.00|
|Edex Continuing Pack||10mcg||1kit Injection||$92.00|
|Edex Continuing Pack||20mcg||1kit Injection||$109.00|
|Edex Continuing Pack||40mcg||3kits Injection||$367.00|
(11alpha,13e,15S)-11,15-Dihydroxy-9-oxoprost-13-en-1-oic acid (13e)-(15S)-11alpha,15-Dihydroxy-9-oxoprost-13-enoate
Teva Parenteral Medicines, Inc.
Humans and other mammals
Indication of Alprostadil
For palliative, not definitive, therapy to temporarily maintain the patency of the ductus arteriosus until corrective or palliative surgery can be performed in neonates who have congenital heart defects and who depend upon the patent ductus for survival. Also for the treatment of erectile dysfunction due to neurogenic, vasculogenic, psychogenic, or mixed etiology.
Toxicity of Alprostadil
Oral, mouse: LDsub50/sub = 186 mg/kg; Oral, rat: LDsub50/sub = 228 mg/kg. Apnea, bradycardia, pyrexia, hypotension, and flushing may be signs of drug overdosage.
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