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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Alprostadil

Muse 125 mcg urethral suppository

$29.39

suppository

* price without discount in nearest pharmacy. Price may vary.

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What is Alprostadil

Alprostadil is produced endogenously and causes vasodilation by means of a direct effect on vascular and ductus arteriosus (DA) smooth muscle, preventing or reversing the functional closure of the DA that occurs shortly after birth. This results in increased pulmonary or systemic blood flow in infants. In infants, it is used for palliative, not definitive, therapy to temporarily maintain the patency of the ductus arteriosus until corrective or palliative surgery can be performed in neonates who have congenital heart defects and who depend upon the patent ductus for survival. In adults, it is used for the treatment of erectile dysfunction due to neurogenic, vasculogenic, psychogenic, or mixed etiology.

Alprostadil mechanism of action

Alprostadil causes vasodilation by means of a direct effect on vascular and ductus arteriosus (DA) smooth muscle, preventing or reversing the functional closure of the DA that occurs shortly after birth. This is because, as a form of prostaglandinE1 (PGE1) it has multiple effects on blood flow. This results in increased pulmonary or systemic blood flow in infants. In cyanotic congenital heart disease, alprostadil’s actions result in an increased oxygen supply to the tissues. In infants with interrupted aortic arch or very severe aortic coarctation, alprostadil maintains distal aortic perfusion by permitting blood flow through the DA from the pulmonary artery to the aorta. In infants with aortic coarctation, alprostadil reduces aortic obstruction either by relaxing ductus tissue in the aortic wall or by increasing effective aortic diameter by dilating the DA. In infants with these aortic arch anomalies, systemic blood flow to the lower body is increased, improving tissue oxygen supply and renal perfusion. When administered by intracavernosal injection or as an intraurethral suppository, alprostadil acts locally to relax the trabecular smooth muscle of the corpora cavernosa and the cavernosal arteries. Swelling, elongation, and rigidity of the penis result when arterial blood rapidly flows into the corpus cavernosum to expand the lacunar spaces. The entrapped blood reduces the venous blood outflow as sinusoids compress against the tunica albuginea.

Dosage forms of Alprostadil

DrugDosageQuantityPrice
Caverject Kit20mcg5vials Solution for Injection$170.00
Caverject Kit20mcg10vials Solution for Injection$306.00
Edex Continuing Pack10mcg1kit Injection$92.00
Edex Continuing Pack20mcg1kit Injection$109.00
Edex Continuing Pack40mcg3kits Injection$367.00
Prescription Generics

true

International Brands

Alprostadil

Synonyms

(11alpha,13e,15S)-11,15-Dihydroxy-9-oxoprost-13-en-1-oic acid (13e)-(15S)-11alpha,15-Dihydroxy-9-oxoprost-13-enoate

Manufacturers

Teva Parenteral Medicines, Inc.

CAS number

745-65-3

UNII

F5TD010360

State

solid

Affected organisms

Humans and other mammals

Indication of Alprostadil

For palliative, not definitive, therapy to temporarily maintain the patency of the ductus arteriosus until corrective or palliative surgery can be performed in neonates who have congenital heart defects and who depend upon the patent ductus for survival. Also for the treatment of erectile dysfunction due to neurogenic, vasculogenic, psychogenic, or mixed etiology.

Toxicity of Alprostadil

Oral, mouse: LDsub50/sub = 186 mg/kg; Oral, rat: LDsub50/sub = 228 mg/kg. Apnea, bradycardia, pyrexia, hypotension, and flushing may be signs of drug overdosage.

RX24 Drugs Disclaimer: before buying a Alprostadil on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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