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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Hexalen

$2,652.89168 capsules/50mg
price without discount in nearest pharmacy. Price may vary.

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Altretamine volume of distribution

The distribution of hexamethylmelamine (HMM) was investigated in surgical biopsies from 12 patients with pelvic cancer who were given an oral dose of 200 mg at 2-24 hours before the operation. The highest concentrations of HMM were found in tissues, such as omentum and subcutaneous tissue, that have a predominant lipidic component. HMM concentrations in the primary tumor were lower than in other tissues and were similar to those in plasma.

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2018 Statistics

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What is Altretamine

An alkylating agent proposed as an antineoplastic. It also acts as a chemosterilant for male houseflies and other insects.

Altretamine mechanism of action

The precise mechanism by which altretamine exerts its cytotoxic effect is unknown although it is classified as an alkylating anti-neoplastic agent. Through this mechanism, the drug is metabolized into alkylating agents by N-demethylation. These alkylating species consequently damage tumor cells.

Dosage forms of Altretamine

Capsuleoral50 mg/1
Capsuleoral50 mg

Prescription Generics


International Brands



2,4,6-Tris(dimethylamino)-1,3,5-triazine 2,4,6-Tris(dimethylamino)-S-triazine


Eisai Inc.

CAS number






Affected organisms

Humans and other mammals

Indication of Altretamine

For use as a single agent in the palliative treatment of patients with persistent or recurrent ovarian cancer following first-line therapy with a cisplatin and/or alkylating agent-based combination.

Toxicity of Altretamine

Altretamine therapy is associated with a low rate of serum enzyme elevations, but these are generally mild and self limited, not requiring dose adjustment. Rare instances of clinically apparent acute liver injury attributed to altretamine have been reported, but the clinical features have not been characterized.

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