Save up -80% on Amifostine
Note: this is a drug discount program, not an insurance plan.
2018 Price of Amifostine
Amifostine 500 mg vial
* price without discount in nearest pharmacy. Price may vary.
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Amifostine volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Amifostine
A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.
Amifostine mechanism of action
The thiol metabolite is responsible for most of the cytoprotective and radioprotective properties of amifostine. It is readily taken up by cells where it binds to and detoxifies reactive metabolites of platinum and alkylating agents as well as scavenges free radicals. Other possible effects include inhibition of apoptosis, alteration of gene expression and modification of enzyme activity.
Dosage forms of Amifostine
|Injection, powder, lyophilized, for solution||intravenous||50 mg/mL|
|Injection, powder, lyophilized, for solution||intravenous||500 mg/10mL|
|Powder for solution||intravenous||500 mg|
Sun Pharmaceutical Industries Limited
Humans and other mammals
Toxicity of Amifostine
Rat LD sub50 /sub: 826 mg/kg
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