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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Amifostine

Amifostine 500 mg vial

$600.0

vial

* price without discount in nearest pharmacy. Price may vary.

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Amifostine volume of distribution

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What is Amifostine

A phosphorothioate proposed as a radiation-protective agent. It causes splenic vasodilation and may block autonomic ganglia.

Amifostine mechanism of action

The thiol metabolite is responsible for most of the cytoprotective and radioprotective properties of amifostine. It is readily taken up by cells where it binds to and detoxifies reactive metabolites of platinum and alkylating agents as well as scavenges free radicals. Other possible effects include inhibition of apoptosis, alteration of gene expression and modification of enzyme activity.

Dosage forms of Amifostine

FormRouteStrength
Injection, powder, lyophilized, for solutionintravenous50 mg/mL
Injection, powder, lyophilized, for solutionintravenous500 mg/10mL
Powder for solutionintravenous500 mg
Prescription Generics

true

International Brands

Amifostine

Synonyms

Amifostina Amifostine

Manufacturers

Sun Pharmaceutical Industries Limited

CAS number

20537-88-6

UNII

ILA426L95O

State

solid

Affected organisms

Humans and other mammals

Indication of Amifostine

For reduction in the cumulative renal toxicity in patients with ovarian cancer (using cisplatin) and moderate to severe xerostomia in patients undergoing post-operative radiation treatment for head and neck cancer.

Toxicity of Amifostine

Rat LD sub50 /sub: 826 mg/kg

RX24 Drugs Disclaimer: before buying a Amifostine on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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