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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Amiloride

Midamor 5 mg tablet

$1.19

tablet

* price without discount in nearest pharmacy. Price may vary.

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Amiloride volume of distribution

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What is Amiloride

A pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with diuretics to spare potassium loss. (From Gilman et al., Goodman and Gilman’s The Pharmacological Basis of Therapeutics, 9th ed, p705)

Amiloride mechanism of action

Amiloride works by inhibiting sodium reabsorption in the distal convoluted tubules and collecting ducts in the kidneys by binding to the amiloride-sensitive sodium channels. This promotes the loss of sodium and water from the body, but without depleting potassium. Amiloride exerts its potassium sparing effect through the inhibition of sodium reabsorption at the distal convoluted tubule, cortical collecting tubule and collecting duct; this decreases the net negative potential of the tubular lumen and reduces both potassium and hydrogen secretion and their subsequent excretion. Amiloride is not an aldosterone antagonist and its effects are seen even in the absence of aldosterone.

Dosage forms of Amiloride

DrugDosageQuantityPrice
Amiloride5mg100 Tablet$60.00
Amiloride/Hctz5/50mg100 Tablet$36.00
Prescription Generics

false

International Brands

Alti-amiloride Hctz

Synonyms

3,5-Diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide Amilorid

Manufacturers

Altimed Pharma Inc.

CAS number

2609-46-3

UNII

7DZO8EB0Z3

State

solid

Affected organisms

Humans and other mammals

Indication of Amiloride

For use as adjunctive treatment with thiazide diuretics or other kaliuretic-diuretic agents in congestive heart failure or hypertension.

Toxicity of Amiloride

No data are available in regard to overdosage in humans. The oral LD sub50 /sub of amiloride hydrochloride (calculated as the base) is 56 mg/kg in mice and 36 to 85 mg/kg in rats, depending on the strain. The most likely signs and symptoms to be expected with overdosage are dehydration and electrolyte imbalance.

RX24 Drugs Disclaimer: before buying a Amiloride on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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