Save up -80% on Amiloride

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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Midamor

$7.9730 tablets/5mg
price without discount in nearest pharmacy. Price may vary.

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We offer free Midamor coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Amiloride every time. What are you waiting for? Claim your prescription drug card now!

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Amiloride volume of distribution

Apparent volume of distribution (Vdβ) ranges from 14 to 17L. Urinary excretion and non-renal elimination contribute almost equally to plasma clearance. The uptake of amiloride is at least 50% and is diminished when given with food. Plasma half-life averages 10h.

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2018 Statistics

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Discount Cards 16,000+

benefit

Clients Benefit 29%

savings

Total savings $4,735,080

What is Amiloride

A pyrazine compound inhibiting sodium reabsorption through sodium channels in renal epithelial cells. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with diuretics to spare potassium loss. (From Gilman et al., Goodman and Gilman’s The Pharmacological Basis of Therapeutics, 9th ed, p705)

Amiloride mechanism of action

Amiloride works by inhibiting sodium reabsorption in the distal convoluted tubules and collecting ducts in the kidneys by binding to the amiloride-sensitive sodium channels. This promotes the loss of sodium and water from the body, but without depleting potassium. Amiloride exerts its potassium sparing effect through the inhibition of sodium reabsorption at the distal convoluted tubule, cortical collecting tubule and collecting duct; this decreases the net negative potential of the tubular lumen and reduces both potassium and hydrogen secretion and their subsequent excretion. Amiloride is not an aldosterone antagonist and its effects are seen even in the absence of aldosterone.

Dosage forms of Amiloride

DrugDosageQuantityPrice
Amiloride5mg100 Tablet$60.00
Amiloride/Hctz5/50mg100 Tablet$36.00

Prescription Generics

false

International Brands

Alti-amiloride Hctz

Synonyms

3,5-Diamino-N-carbamimidoyl-6-chloropyrazine-2-carboxamide Amilorid

Manufacturers

Altimed Pharma Inc.

CAS number

2609-46-3

UNII

7DZO8EB0Z3

State

solid

Affected organisms

Humans and other mammals

Indication of Amiloride

For use as adjunctive treatment with thiazide diuretics or other kaliuretic-diuretic agents in congestive heart failure or hypertension.

Toxicity of Amiloride

No data are available in regard to overdosage in humans. The oral LD sub50 /sub of amiloride hydrochloride (calculated as the base) is 56 mg/kg in mice and 36 to 85 mg/kg in rats, depending on the strain. The most likely signs and symptoms to be expected with overdosage are dehydration and electrolyte imbalance.

RX24 Drugs Disclaimer: consult your healthcare provider before buying a Amiloride on prescription or using an RX manufacturer savings coupon. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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