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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Amicar

$1,218.2860 tablets/500 mg
Price with discount in nearest pharmacy. Price may vary.

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Aminocaproic Acid volume of distribution

PK parameters for this typical patient were: pre-/postoperative plasma drug clearance of 32 ml min(-1) (3.6 ml kg(-1) min(-1)), inter-compartmental clearance of 42.4 ml min(-1) (4.8 ml min(-1) kg(-1)), central volume of distribution of 1.27 litre (0.14 litre kg(-1)), and peripheral volume of distribution of 2.53 litre (0.29 litre kg(-1)). Intra-operative clearance and central volume of distribution were 89% and 80% of the pre-/postoperative value, respectively.

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What is Aminocaproic Acid

An antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties.

Aminocaproic Acid mechanism of action

Aminocaproic acid binds reversibly to the kringle domain of plasminogen and blocks the binding of plasminogen to fibrin and its activation to plasmin. With NO activation of plasmin, there is a reduction in fibrinolysis. This consequently will reduce the amount of bleeding post surgery. Elevated plasma levels of lipoprotein(a) have been shown to increase the risk of vascular disease. Lipoprotein 9a)a has two components, apolipoprotein B-100, linked to apolipoprotein (a). Aminocaproic acid may change the conformation of apoliprotein (a), changing its binding properties and potentially preventing the formation of lipoprotein (a).

Dosage forms of Aminocaproic Acid

Solutionoral.25 g/mL
Tabletoral1000 mg/1
Tabletoral500 mg/1

Prescription Generics


International Brands



6-Aminocaproic acid 6-aminohexanoic acid


Clover Pharmaceuticals Corp.

CAS number






Affected organisms

Humans and other mammals

Indication of Aminocaproic Acid

For use in the treatment of excessive postoperative bleeding.

Toxicity of Aminocaproic Acid

A few cases of acute overdosage with intravenous administration have been reported. The effects have ranged from no reaction to transient hypotension to severe acute renal failure leading to death. The intravenous and oral LD sub50 /sub were 3.0 and 12.0 g/kg respectively in the mouse and 3.2 and 16.4 g/kg respectively in the rat. An intravenous infusion dose of 2.3 g/kg was lethal in the dog.

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