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Price of Aminocaproic Acid
Aminocaproic acid 500 mg tablet
* price without discount in nearest pharmacy. Price may vary.
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Aminocaproic Acid volume of distribution
* 23.1 6.6 L
What is Aminocaproic Acid
An antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties. (PubChem)
Aminocaproic Acid mechanism of action
Aminocaproic acid binds reversibly to the kringle domain of plasminogen and blocks the binding of plasminogen to fibrin and its activation to plasmin. With NO activation of plasmin, there is a reduction in fibrinolysis. This consequently will reduce the amount of bleeding post surgery. Elevated plasma levels of lipoprotein(a) have been shown to increase the risk of vascular disease. Lipoprotein 9a)a has two components, apolipoprotein B-100, linked to apolipoprotein (a). Aminocaproic acid may change the conformation of apoliprotein (a), changing its binding properties and potentially preventing the formation of lipoprotein (a).
Dosage forms of Aminocaproic Acid
Clover Pharmaceuticals Corp.
Humans and other mammals
Indication of Aminocaproic Acid
For use in the treatment of excessive postoperative bleeding.
Toxicity of Aminocaproic Acid
A few cases of acute overdosage with intravenous administration have been reported. The effects have ranged from no reaction to transient hypotension to severe acute renal failure leading to death. The intravenous and oral LD sub50 /sub were 3.0 and 12.0 g/kg respectively in the mouse and 3.2 and 16.4 g/kg respectively in the rat. An intravenous infusion dose of 2.3 g/kg was lethal in the dog.
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