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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Amicar

$1,218.2860 tablets/500 mg
price without discount in nearest pharmacy. Price may vary.

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Aminocaproic Acid volume of distribution

* 23.1 6.6 L

RX Prescription
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2018 Statistics

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Clients Benefit 29%

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Total savings $4,735,080

What is Aminocaproic Acid

An antifibrinolytic agent that acts by inhibiting plasminogen activators which have fibrinolytic properties.

Aminocaproic Acid mechanism of action

Aminocaproic acid binds reversibly to the kringle domain of plasminogen and blocks the binding of plasminogen to fibrin and its activation to plasmin. With NO activation of plasmin, there is a reduction in fibrinolysis. This consequently will reduce the amount of bleeding post surgery. Elevated plasma levels of lipoprotein(a) have been shown to increase the risk of vascular disease. Lipoprotein 9a)a has two components, apolipoprotein B-100, linked to apolipoprotein (a). Aminocaproic acid may change the conformation of apoliprotein (a), changing its binding properties and potentially preventing the formation of lipoprotein (a).

Dosage forms of Aminocaproic Acid

FormRouteStrength
Solutionoral.25 g/mL
Tabletoral1000 mg/1
Tabletoral500 mg/1

Prescription Generics

false

International Brands

Amicar

Synonyms

6-Aminocaproic acid 6-aminohexanoic acid

Manufacturers

Clover Pharmaceuticals Corp.

CAS number

60-32-2

UNII

U6F3787206

State

solid

Affected organisms

Humans and other mammals

Indication of Aminocaproic Acid

For use in the treatment of excessive postoperative bleeding.

Toxicity of Aminocaproic Acid

A few cases of acute overdosage with intravenous administration have been reported. The effects have ranged from no reaction to transient hypotension to severe acute renal failure leading to death. The intravenous and oral LD sub50 /sub were 3.0 and 12.0 g/kg respectively in the mouse and 3.2 and 16.4 g/kg respectively in the rat. An intravenous infusion dose of 2.3 g/kg was lethal in the dog.

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