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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Aminolevulinic acid

Levulan kerastick

$170.25

each

* price without discount in nearest pharmacy. Price may vary.

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Aminolevulinic acid volume of distribution

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What is Aminolevulinic acid

A compound produced from succinyl-CoA and glycine as an intermediate in heme synthesis. It is used as a photochemotherapy for actinic keratosis.

Aminolevulinic acid mechanism of action

According to the presumed mechanism of action, photosensitization following application of aminolevulinic acid (ALA) topical solution occurs through the metabolic conversion of ALA to protoporphyrin IX (PpIX), which accumulates in the skin to which aminolevulinic acid has been applied. When exposed to light of appropriate wavelength and energy, the accumulated PpIX produces a photodynamic reaction, a cytotoxic process dependent upon the simultaneous presence of light and oxygen. The absorption of light results in an excited state of the porphyrin molecule, and subsequent spin transfer from PpIX to molecular oxygen generates singlet oxygen, which can further react to form superoxide and hydroxyl radicals. Photosensitization of actinic (solar) keratosis lesions using aminolevulinic acid, plus illumination with the BLU-UTM Blue Light Photodynamic Therapy Illuminator (BLU-U), is the basis for aminolevulinic acid photodynamic therapy (PDT).

Dosage forms of Aminolevulinic acid

FormRouteStrength
GelCutaneous use78 mg/g
Geltopical100 mg/g
Powder for oralsolutionOral use30 mg/ml
Prescription Generics

false

International Brands

Ameluz

Synonyms

5-ALA 5-Amino-4-oxopentanoate

Manufacturers

Biofrontera Inc.

CAS number

106-60-5

UNII

88755TAZ87

State

solid

Affected organisms

Humans and other mammals

Indication of Aminolevulinic acid

Aminolevulinic acid plus blue light illumination using a blue light photodynamic therapy illuminator is indicated for the treatment of minimally to moderately thick actinic keratoses of the face or scalp.

Toxicity of Aminolevulinic acid

Solution overdose have not been reported.

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