Save up -80% on Aminosalicylic Acid
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2018 Price of Aminosalicylic Acid
Aminosalicylic acid powder
* price without discount in nearest pharmacy. Price may vary.
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Aminosalicylic Acid volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
Aminosalicylic Acid mechanism of action
There are two mechanisms responsible for aminosalicylic acid’s bacteriostatic action against i Mycobacterium tuberculosis /i . Firstly, aminosalicylic acid inhibits folic acid synthesis (without potentiation with antifolic compounds). The binding of para-aminobenzoic acid to pteridine synthetase acts as the first step in folic acid synthesis. Aminosalicylic acid binds pteridine synthetase with greater affinity than para-aminobenzoic acid, effectively inhibiting the synthesis of folic acid. As bacteria are unable to use external sources of folic acid, cell growth and multiplication slows. Secondly, aminosalicylic acid may inhibit the synthesis of the cell wall component, mycobactin, thus reducing iron uptake by i M. tuberculosis /i .
Dosage forms of Aminosalicylic Acid
|Gastro-resistant v granules||Oral use||4 g|
|Granule, delayed release||oral||4 g/1|
Nemasol Sodium Tab 500mg
4-amino-2-hydroxybenzoic acid 4-aminosalicylate
Icn Canada Ltd.
Indication of Aminosalicylic Acid
For the treatment of tuberculosis
Toxicity of Aminosalicylic Acid
LD sub 50 /sub =4 gm/kg (orally in mice); LD sub 50 /sub =3650 mg/kg (orally in rabbits)
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