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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Aminosalicylic Acid

Aminosalicylic acid powder

$2.4

g

* price without discount in nearest pharmacy. Price may vary.

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Aminosalicylic Acid volume of distribution

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What is Aminosalicylic Acid

An antitubercular agent often administered in association with isoniazid. The sodium salt of the drug is better tolerated than the free acid.

Aminosalicylic Acid mechanism of action

There are two mechanisms responsible for aminosalicylic acid’s bacteriostatic action against i Mycobacterium tuberculosis /i . Firstly, aminosalicylic acid inhibits folic acid synthesis (without potentiation with antifolic compounds). The binding of para-aminobenzoic acid to pteridine synthetase acts as the first step in folic acid synthesis. Aminosalicylic acid binds pteridine synthetase with greater affinity than para-aminobenzoic acid, effectively inhibiting the synthesis of folic acid. As bacteria are unable to use external sources of folic acid, cell growth and multiplication slows. Secondly, aminosalicylic acid may inhibit the synthesis of the cell wall component, mycobactin, thus reducing iron uptake by i M. tuberculosis /i .

Dosage forms of Aminosalicylic Acid

FormRouteStrength
Gastro-resistant v granulesOral use4 g
Tabletoral500 mg
Granule, delayed releaseoral4 g/1
Prescription Generics

false

International Brands

Nemasol Sodium Tab 500mg

Synonyms

4-amino-2-hydroxybenzoic acid 4-aminosalicylate

Manufacturers

Icn Canada Ltd.

CAS number

65-49-6

UNII

5B2658E0N2

State

solid

Affected organisms

Mycobacteria

Indication of Aminosalicylic Acid

For the treatment of tuberculosis

Toxicity of Aminosalicylic Acid

LD sub 50 /sub =4 gm/kg (orally in mice); LD sub 50 /sub =3650 mg/kg (orally in rabbits)

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