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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Norvasc

$6.0330 tablet/10 mg
Price with discount in nearest pharmacy. Price may vary.

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Amlodipine volume of distribution

Volume of distribution is large (21 L/kg) and there is a high degree of protein binding (98%)

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What is Amlodipine

Amlodipine is a long-acting 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, amlodipine prevents calcium-dependent myocyte contraction and vasoconstriction. A second proposed mechanism for the drugs vasodilatory effects involves pH-dependent inhibition of calcium influx via inhibition of smooth muscle carbonic anhydrase. Some studies have shown that amlodipine also exerts inhibitory effects on voltage-gated N-type calcium channels. N-type calcium channels located in the central nervous system may be involved in nociceptive signaling and pain sensation. Amlodipine is used to treat hypertension and chronic stable angina.

Amlodipine mechanism of action

Amlodipine decreases arterial smooth muscle contractility and subsequent vasoconstriction by inhibiting the influx of calcium ions through L-type calcium channels. Calcium ions entering the cell through these channels bind to calmodulin. Calcium-bound calmodulin then binds to and activates myosin light chain kinase (MLCK). Activated MLCK catalyzes the phosphorylation of the regulatory light chain subunit of myosin, a key step in muscle contraction. Signal amplification is achieved by calcium-induced calcium release from the sarcoplasmic reticulum through ryanodine receptors. Inhibition of the initial influx of calcium decreases the contractile activity of arterial smooth muscle cells and results in vasodilation. The vasodilatory effects of amlodipine result in an overall decrease in blood pressure. Amlodipine is a long-acting CCB that may be used to treat mild to moderate essential hypertension and exertion-related angina (chronic stable angina). Another possible mechanism is that amlodipine inhibits vascular smooth muscle carbonic anhydrase I activity causing cellular pH increases which may be involved in regulating intracelluar calcium influx through calcium channels.

Dosage forms of Amlodipine

DrugDosageQuantityPrice
Amlodipine2.5mg90 Tablet$54.00
Amlodipine5mg100 Tablet$65.00
Norvasc5mg90 Tablet$133.00
Norvasc10mg90 Tablet$148.00
Caduet5/20mg30 Tablet$122.00
Caduet10/80mg90 Tablet$365.90
Exforge5/320mg28 Film Coated Tablet$63.00
Exforge10/320mg84 film coated tablet$172.75
Exforge HCT5/160/12.5mg84 Tablet$192.00
Azor5/20mg90 Tablet$125.00
Azor10/40mg84 Tablet$180.00
Twynsta5/80mg84 Tablet$279.00
Twynsta10/40mg84 Tablet$279.00
Tribenzor20/5/12.5mg84 Tablet$191.00
Tribenzor40/5/12.5mg90 Tablet$153.00

Prescription Generics

false

International Brands

Accel-amlodipine

Synonyms

(RS)-3-ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate 3-Ethyl 5-methylester, ()-2-((2-aminoethoxy)methyl)-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate

Manufacturers

Accel Pharma Inc

CAS number

88150-42-9

UNII

1J444QC288

State

solid

Affected organisms

Humans and other mammals

Indication of Amlodipine

For the treatment of hypertension and chronic stable angina.

Toxicity of Amlodipine

Gross overdosage could result in excessive peripheral vasodilatation and possibly reflex tachycardia. Marked and probably prolonged systemic hypotension up to an including shock with fatal outcome have been reported.

RX24 Drugs Disclaimer: consult your healthcare provider before buying a Amlodipine on prescription or using an RX manufacturer savings coupon. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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What is Norvasc?

Norvasc is a calcium channel blocker that dilates blood vessels and improves circulation. Norvasc is used to treat chest pain (angina) and other conditions caused by coronary artery disease. Norvasc is also used to treat high blood pressure (hypertension). Lowering blood pressure can reduce the risk of stroke or heart attack. Amlodipine is intended for adults and children who are at least 6 years old.

Before taking Norvasc, tell your doctor if you have congestive heart failure or liver disease. Drinking alcohol can lower blood pressure even more and may increase some side effects of Norvasc. If you are being treated for high blood pressure, continue using Norvasc, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.

Norvasc is only part of a complete treatment program, which may also include diet, exercise, weight control, and other medications. Watch your diet, medications and exercises very carefully. Tell your doctor about all other heart or blood pressure medications you are taking. Chest pain may worsen when you first take this medicine or when your dose is increased. Call your doctor if chest pain is severe or continues.

What is Tribenzor?

Tribenzor contains a combination of amlodipine, hydrochlorothiazide, and olmesartanan. Amlodipine is a calcium channel blocker that relaxes (dilates) blood vessels and improves circulation. Hydrochlorothiazide is a thiazide diuretic (water tablet) that helps prevent your body from absorbing too much salt, which can cause fluid retention.

Olmesartan is an angiotensin II receptor antagonist that keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow. Tribenzor is used to treat high blood pressure (hypertension). Tribenzor is usually given after other blood pressure medications have been tried without successful treatment.

You should not take Tribenzor if you are allergic to sulfa drugs, or if you cannot urinate. Do not use Tribenzor if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away. If you have diabetes, do not use Tribenzor with any medicine that contains aliskiren (Amturnide, Tekturna, Tekamlo).