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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Amlodipine

Amlodipine 10 mg Tablet

$1.03

tablet

* price without discount in nearest pharmacy. Price may vary.

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Amlodipine volume of distribution

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What is Amlodipine

Amlodipine is a long-acting 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, amlodipine prevents calcium-dependent myocyte contraction and vasoconstriction. A second proposed mechanism for the drugs vasodilatory effects involves pH-dependent inhibition of calcium influx via inhibition of smooth muscle carbonic anhydrase. Some studies have shown that amlodipine also exerts inhibitory effects on voltage-gated N-type calcium channels. N-type calcium channels located in the central nervous system may be involved in nociceptive signaling and pain sensation. Amlodipine is used to treat hypertension and chronic stable angina.

Amlodipine mechanism of action

Amlodipine decreases arterial smooth muscle contractility and subsequent vasoconstriction by inhibiting the influx of calcium ions through L-type calcium channels. Calcium ions entering the cell through these channels bind to calmodulin. Calcium-bound calmodulin then binds to and activates myosin light chain kinase (MLCK). Activated MLCK catalyzes the phosphorylation of the regulatory light chain subunit of myosin, a key step in muscle contraction. Signal amplification is achieved by calcium-induced calcium release from the sarcoplasmic reticulum through ryanodine receptors. Inhibition of the initial influx of calcium decreases the contractile activity of arterial smooth muscle cells and results in vasodilation. The vasodilatory effects of amlodipine result in an overall decrease in blood pressure. Amlodipine is a long-acting CCB that may be used to treat mild to moderate essential hypertension and exertion-related angina (chronic stable angina). Another possible mechanism is that amlodipine inhibits vascular smooth muscle carbonic anhydrase I activity causing cellular pH increases which may be involved in regulating intracelluar calcium influx through calcium channels.

Dosage forms of Amlodipine

DrugDosageQuantityPrice
Amlodipine2.5mg90 Tablet$54.00
Amlodipine5mg100 Tablet$65.00
Norvasc5mg90 Tablet$133.00
Norvasc10mg90 Tablet$148.00
Caduet5/20mg30 Tablet$122.00
Caduet10/80mg90 Tablet$365.90
Exforge5/320mg28 Film Coated Tablet$63.00
Exforge10/320mg84 film coated tablet$172.75
Exforge HCT5/160/12.5mg84 Tablet$192.00
Azor5/20mg90 Tablet$125.00
Azor10/40mg84 Tablet$180.00
Twynsta5/80mg84 Tablet$279.00
Twynsta10/40mg84 Tablet$279.00
Tribenzor20/5/12.5mg84 Tablet$191.00
Tribenzor40/5/12.5mg90 Tablet$153.00
Prescription Generics

false

International Brands

Accel-amlodipine

Synonyms

(RS)-3-ethyl 5-methyl 2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate 3-Ethyl 5-methylester, ()-2-((2-aminoethoxy)methyl)-4-(o-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate

Manufacturers

Accel Pharma Inc

CAS number

88150-42-9

UNII

1J444QC288

State

solid

Affected organisms

Humans and other mammals

Indication of Amlodipine

For the treatment of hypertension and chronic stable angina.

Toxicity of Amlodipine

Gross overdosage could result in excessive peripheral vasodilatation and possibly reflex tachycardia. Marked and probably prolonged systemic hypotension up to an including shock with fatal outcome have been reported.

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