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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Amobarbital

Amytal sodium 0.5 gram vial

$117.35

vial

* price without discount in nearest pharmacy. Price may vary.

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Amobarbital volume of distribution

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What is Amobarbital

A barbiturate with hypnotic and sedative properties (but not antianxiety). Adverse effects are mainly a consequence of dose-related CNS depression and the risk of dependence with continued use is high. (From Martindale, The Extra Pharmacopoeia, 30th ed, p565)

Amobarbital mechanism of action

Amobarbital (like all barbiturates) works by binding to the GABAA receptor at either the alpha or the beta sub unit. These are binding sites that are distinct from GABA itself and also distinct from the benzodiazepine binding site. Like benzodiazepines, barbiturates potentiate the effect of GABA at this receptor. This GABAA receptor binding decreases input resistance, depresses burst and tonic firing, especially in ventrobasal and intralaminar neurons, while at the same time increasing burst duration and mean conductance at individual chloride channels; this increases both the amplitude and decay time of inhibitory postsynaptic currents. In addition to this GABA-ergic effect, barbiturates also block the AMPA receptor, a subtype of glutamate receptor. Glutamate is the principal excitatory neurotransmitter in the mammalian CNS. Amobarbital also appears to bind neuronal nicotinic acetylcholine receptors.

Dosage forms of Amobarbital

FormRouteStrength
Injection, powder, lyophilized, for solutionintramuscular; intravenous.5 g/5mL
Powder for solutionintramuscular; intravenous500 mg
Capsuleoral60 mg
Prescription Generics

false

International Brands

Amytal Sodium

Synonyms

5-Ethyl-5-(3-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidinetrione 5-Ethyl-5-(3-methylbutyl)barbituric acid

Manufacturers

Marathon Pharmaceuticals, LLC

CAS number

57-43-2

UNII

GWH6IJ239E

State

solid

Affected organisms

Indication of Amobarbital

Toxicity of Amobarbital

RX24 Drugs Disclaimer: before buying a Amobarbital on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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