Save up -80% on Amobarbital
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2018 Price of Amobarbital
Amytal sodium 0.5 gram vial
* price without discount in nearest pharmacy. Price may vary.
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Amobarbital volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Amobarbital
A barbiturate with hypnotic and sedative properties (but not antianxiety). Adverse effects are mainly a consequence of dose-related CNS depression and the risk of dependence with continued use is high. (From Martindale, The Extra Pharmacopoeia, 30th ed, p565)
Amobarbital mechanism of action
Amobarbital (like all barbiturates) works by binding to the GABAA receptor at either the alpha or the beta sub unit. These are binding sites that are distinct from GABA itself and also distinct from the benzodiazepine binding site. Like benzodiazepines, barbiturates potentiate the effect of GABA at this receptor. This GABAA receptor binding decreases input resistance, depresses burst and tonic firing, especially in ventrobasal and intralaminar neurons, while at the same time increasing burst duration and mean conductance at individual chloride channels; this increases both the amplitude and decay time of inhibitory postsynaptic currents. In addition to this GABA-ergic effect, barbiturates also block the AMPA receptor, a subtype of glutamate receptor. Glutamate is the principal excitatory neurotransmitter in the mammalian CNS. Amobarbital also appears to bind neuronal nicotinic acetylcholine receptors.
Dosage forms of Amobarbital
|Injection, powder, lyophilized, for solution||intramuscular; intravenous||.5 g/5mL|
|Powder for solution||intramuscular; intravenous||500 mg|
5-Ethyl-5-(3-methylbutyl)-2,4,6(1H,3H,5H)-pyrimidinetrione 5-Ethyl-5-(3-methylbutyl)barbituric acid
Marathon Pharmaceuticals, LLC
Indication of Amobarbital
Toxicity of Amobarbital
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