Save up -80% on Amphotericin B
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Amphotericin B
Abelcet 5 mg/ml vial p-f
|price without discount in nearest pharmacy. Price may vary.|
We offer free Amphotericin B coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your discount card in most local pharmacies to get a discount on Amphotericin B every time. What are you waiting for? Claim your prescription drug card now!
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Amphotericin B volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Amphotericin B
Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphotericin B ranging from 0.03 to 1.0 mcg/mL in vitro. While Candida albicans is generally quite susceptible to amphotericin B, non-albicans species may be less susceptible. Pseudallescheria boydii and Fusarium sp. are often resistant to amphotericin B. The antibiotic is without effect on bacteria, rickettsiae, and viruses.
Amphotericin B mechanism of action
Amphotericin B is fungistatic or fungicidal depending on the concentration obtained in body fluids and the susceptibility of the fungus. The drug acts by binding to sterols (ergosterol) in the cell membrane of susceptible fungi. This creates a transmembrane channel, and the resultant change in membrane permeability allowing leakage of intracellular components. Ergosterol, the principal sterol in the fungal cytoplasmic membrane, is the target site of action of amphotericin B and the azoles. Amphotericin B, a polyene, binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.
Dosage forms of Amphotericin B
|Injection, powder, lyophilized, for solution||intravenous||50 mg/12.5mL|
|Powder for solution||intravenous||50 mg|
Amfotericina B AMPH-b
Sigma Tau Pharmaceuticals Inc
Various Fungus Species
Indication of Amphotericin B
Used to treat potentially life threatening fungal infections.
Toxicity of Amphotericin B
Oral, rat: LD sub50 /sub = 5 gm/kg. Amphotericin B overdoses can result in cardio-respiratory arrest.
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