Save up -80% on Amphotericin B

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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Amphotericin B

Abelcet 5 mg/ml vial p-f

$12.0ml
price without discount in nearest pharmacy. Price may vary.

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Amphotericin B volume of distribution

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What is Amphotericin B

Amphotericin B shows a high order of in vitro activity against many species of fungi. Histoplasma capsulatum, Coccidioides immitis, Candida species, Blastomyces dermatitidis, Rhodotorula, Cryptococcus neoformans, Sporothrix schenckii, Mucor mucedo, and Aspergillus fumigatus are all inhibited by concentrations of amphotericin B ranging from 0.03 to 1.0 mcg/mL in vitro. While Candida albicans is generally quite susceptible to amphotericin B, non-albicans species may be less susceptible. Pseudallescheria boydii and Fusarium sp. are often resistant to amphotericin B. The antibiotic is without effect on bacteria, rickettsiae, and viruses.

Amphotericin B mechanism of action

Amphotericin B is fungistatic or fungicidal depending on the concentration obtained in body fluids and the susceptibility of the fungus. The drug acts by binding to sterols (ergosterol) in the cell membrane of susceptible fungi. This creates a transmembrane channel, and the resultant change in membrane permeability allowing leakage of intracellular components. Ergosterol, the principal sterol in the fungal cytoplasmic membrane, is the target site of action of amphotericin B and the azoles. Amphotericin B, a polyene, binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death.

Dosage forms of Amphotericin B

FormRouteStrength
Suspensionintravenous5 mg
Injection, powder, lyophilized, for solutionintravenous50 mg/12.5mL
Powder for solutionintravenous50 mg

Prescription Generics

false

International Brands

Abelcet

Synonyms

Amfotericina B AMPH-b

Manufacturers

Sigma Tau Pharmaceuticals Inc

CAS number

1397-89-3

UNII

7XU7A7DROE

State

solid

Affected organisms

Various Fungus Species

Indication of Amphotericin B

Used to treat potentially life threatening fungal infections.

Toxicity of Amphotericin B

Oral, rat: LD sub50 /sub = 5 gm/kg. Amphotericin B overdoses can result in cardio-respiratory arrest.

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