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Price of Anakinra
Kineret 100 mg/0.67 ml syr
* price without discount in nearest pharmacy. Price may vary.
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Anakinra volume of distribution
What is Anakinra
Anakinra is a recombinant, nonglycosylated human interleukin-1 receptor antagonist (IL-1Ra). The difference between anakinra and the native human IL-1Ra is that anakinra has an extra methionine residue at the amino terminus. It is manufactured by using the E. coli expression system. Anakinra is composed of 153 amino acid residues. FDA approved on November 14, 2001.
Anakinra mechanism of action
Anakinra binds competitively to the Interleukin-1 type I receptor (IL-1RI), thereby inhibiting the action of elevated levels IL-1 which normally can lead to cartilage degradation and bone resorption.
Dosage forms of Anakinra
|Injection, solution||subcutaneous||100 mg/.67mL|
|Solution for injection||Subcutaneous use||100 mg|
SWEDISH ORPHAN BIOVITRUM AB (PUBL)
Humans and other mammals
Indication of Anakinra
For the treatment of adult rheumatoid arthritis and treatment of Neonatal-Onset Multisystem Inflammatory Disease (NOMID).
Toxicity of Anakinra
Most common adverse reactions (incidence ? 5%) are injection site reaction, worsening of rheumatoid arthritis, upper respiratory tract infection, headache, nausea, diarrhea, sinusitis, arthralgia, flu like-symptoms, and abdominal pain when anakinra is used in RA patients. In NOMID patients, the most common AEs during the first 6 months of treatment (incidence 10%) are injection site reaction, headache, vomiting, arthralgia, pyrexia, and nasopharyngitis.
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