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Price of Anidulafungin
Eraxis(water dil) 50 mg vial
* price without discount in nearest pharmacy. Price may vary.
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Anidulafungin volume of distribution
* 30 to 50 L
What is Anidulafungin
Anidulafungin or Eraxis is an anti-fungal drug manufactured by Pfizer that gained approval by the Food and Drug Administration (FDA) in February 21, 2006; it was previously known as LY303366. There is preliminary evidence that it has a similar safety profile to caspofungin. (Wikipedia)
Anidulafungin mechanism of action
Anidulafungin is a semi-synthetic echinocandin with antifungal activity. Anidulafungin inhibits glucan synthase, an enzyme present in fungal, but not mammalian cells. This results in inhibition of the formation of 1,3- beta;-D-glucan, an essential component of the fungal cell wall, ultimately leading to osmotic instability and cell death.
Dosage forms of Anidulafungin
|Injection, powder, lyophilized, for solution||intravenous||100 mg/30mL|
|Injection, powder, lyophilized, for solution||intravenous||50 mg/15mL|
|Powder for solution||intravenous||100 mg|
(4R,5R)-4,5-Dihydroxy-N-((4”-(pentyloxy)-p-terphenyl-4-yl)carbonyl)-L-ornithyl-L-threonyl-trans-4-hydroxy-L-prolyl-(S)-4-hydroxy-4(p-hydroxyphenyl)-L-threonyl-L-threonyl-(3S,4S)-3-hydroxy-4-methyl-L-proline cyclic (6- 1)-peptide
Pfizer Canada Inc
Candida albicans and other yeasts
Indication of Anidulafungin
For use in the treatment of the following fungal infections: Candidemia and other forms of i Candida /i infections (intra-abdominal abscess, and peritonitis), Aspergillus infections, and esophageal candidiasis. Also considered an alternative treatment for oropharyngeal canaidiasis.
Toxicity of Anidulafungin
During clinical trials a single 400 mg dose of anidulafungin was inadvertently administered as a loading dose. No clinical adverse events were reported. The maximum non-lethal dose of anidulafungin in rats was 50 mg/kg, a dose which is equivalent to 10 times the recommended daily dose for esophageal candidiasis (50mg/day).
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