Save up -80% on Anti-thymocyte Globulin (Equine)
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2018 Price of Anti-thymocyte Globulin (Equine)
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Anti-thymocyte Globulin (Equine) volume of distribution
During infusion of 10 to 15 mg/kg/day, the mean peak value (n = 27 renal transplant patients) was found to be 727 310 g/mL.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Anti-thymocyte Globulin (Equine)
Equine anti-thymocyte globulin is composed of purified gamma globulin containing primarily IgG against human thymus lymphocytes. It is formed by inoculating a horse with an antigen (human thymoyctes) which then induces the horse immune system’s B-lymphocytes to produce IgG immunoglobulins specific for that antigen. The result is polyclonal IgG that is then purified from the horse’s serum to produce a usable drug product that can be used for immunosuppression. Although the exact mechanism of action is unknown, equine anti-thymocyte globulin targets a variety of immune system proteins including lymphocyte surface proteins, granulocytes, platelets, bone marrow cells, and other cell types. Equine ATG is currently indicated for the suppression of the immune system to prevent renal transplant rejection and in the treatment of aplastic anemia. Induction of T cell apoptosis and resulting T-cell lymphopenia found in vivo is credited for its therapeutic effect in these conditions. There are currently various ATG products available, which differ in the source of inoculated animal (rabbit, horse, or pig) and in the type of antigen product used to produce immunoglobulin (thymocytes, peripheral T cells, etc.).
Anti-thymocyte Globulin (Equine) mechanism of action
Dosage forms of Anti-thymocyte Globulin (Equine)
|Injection, solution||intravenous||50 mg/mL|
eATG equine ATG
Pharmacia And Upjohn Company Llc
Indication of Anti-thymocyte Globulin (Equine)
For prevention of renal transplant rejection and for the treatment of aplastic anemia.
Toxicity of Anti-thymocyte Globulin (Equine)
The most commonly reported adverse reactions (occurring in greater than 10% of patients) are pyrexia, chills, rash, thrombocytopenia, leukopenia and arthralgia.
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