Save up -80% on Aripiprazole
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
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2019 Price of Abilify
|$19.04||30 tablets/5 mg|
|price without discount in nearest pharmacy. Price may vary.|
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Aripiprazole volume of distribution
The single-dose pharmacokinetics of aripiprazole were linear and dose-proportional between the doses of 5 to 30 mg. The steady-state volume of distribution of aripiprazole following intravenous administration is high (404 L or 4.9 L/kg), indicating extensive extravascular distribution.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Aripiprazole
Aripiprazole is an atypical antipsychotic medication used for the treatment of schizophrenia. It has also recently received FDA approval for the treatment of acute manic and mixed episodes associated with bipolar disorder. Aripiprazole appears to mediate its antipsychotic effects primarily by partial agonism at the D2 receptor. In addition to partial agonist activity at the D2 receptor, aripiprazole is also a partial agonist at the 5-HT1A receptor, and like the other atypical antipsychotics, aripiprazole displays an antagonist profile at the 5-HT2A receptor. Aripiprazole has moderate affinity for histamine and alpha adrenergic receptors, and no appreciable affinity for cholinergic muscarinic receptors.
Aripiprazole mechanism of action
Aripiprazole’s antipsychotic activity is likely due to a combination of antagonism at D2 receptors in the mesolimbic pathway and 5HT2A receptors in the frontal cortex. Antagonism at D2 receptors relieves positive symptoms while antagonism at 5HT2A receptors relieves negative symptoms of schizophrenia.
Dosage forms of Aripiprazole
|Aripiprazole||5mg||100 Orally Disintegrating Tablet||$37.00|
|Aripiprazole||10mg||100 Orally Disintegrating Tablet||$44.00|
|Aripiprazole||15mg||100 Orally Disintegrating Tablet||$57.00|
|Abilify Oral Solution||1mg/ml||150ml Oral Solution||$261.00|
|Abilify Discmelt||10mg||28 Dispersible Tablet||$194.00|
|Abilify Discmelt||10mg||84 Dispersible Tablet||$563.00|
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Humans and other mammals
Indication of Aripiprazole
For the treatment of schizophrenia and related psychotic disorders.
Toxicity of Aripiprazole
A potentially fatal symptom complex sometimes referred to as Neuroleptic Malignant Syndrome (NMS) has been reported in association with administration of antipsychotic drugs, including aripiprazole. Two possible cases of NMS occurred during aripiprazole treatment in the premarketing worldwide clinical database. Clinical manifestations of NMS are hyperpyrexia, muscle rigidity, altered mental status, and evidence of autonomic instability (irregular pulse or blood pressure, tachycardia, diaphoresis, and cardiac dysrhythmia). Additional signs may include elevated creatine phosphokinase, myoglobinuria (rhabdomyolysis), and acute renal failure. Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. Antidepressants increased the risk compared to placebo of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults in short-term studies of major depressive disorder (MDD) and other psychiatric disorders.
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What is Abilify?
Abilify is a neuroleptic drug. The composition includes aripiprazole drug Abilify – a substance having a high affinity for D3- and D2-dopamine receptors, serotonin receptors and 5HT1a 5HT2a, and moderate affinity for the serotonin receptor 5HT2c and 5HT7, D4-dopamine receptors, histamine H1 receptors and alpha 1-adrenoceptors (according to in vitro studies).
The therapeutic effect of the drug Abilify in schizophrenia is realized due to the agonistic effect of aripiprazole on the 5HT1a serotonin receptors and D2-dopamine receptors, as well as the antagonistic effect on the 5HT2 serotonin receptors. Some effects of aripiprazole are realized at the expense of affinity not only for dopamine and serotonin receptors.
Abilify is characterized by some affinity for sites that regulate the reuptake of serotonin. Aripiprazole has no affinity for muscarinic receptors. During animal experiments, agonism for dopaminergic hypoactivity and antagonism for dopaminergic hyperactivity have been established.