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2018 Price of Armodafinil
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Armodafinil volume of distribution
Apparent volume of distribution: 42L.
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What is Armodafinil
Armodafinil is the enantiopure of the wakefulness-promoting agent modafinil (Provigil), and is indicated to improve wakefulness in adult patients with excessive sleepiness associated with obstructive sleep apnea (OSA), narcolepsy, or shift work disorder (SWD). Research has shown that armodafinil significantly improves driving simulator performance in patients with SWD. Armodafinil consists of the ( )-R-enantiomer of the racemic modafinil. Armodafinil is produced by the pharmaceutical company Cephalon Inc. (a wholly owned subsidiary of Teva Pharmaceutical Industries Ltd.) and was approved by the U.S. Food and Drug Administration (FDA) in June 2007.
Armodafinil mechanism of action
Nuvigil (armodafinil) is a single-isomer of modafini. The exact mechanism of action is unknown. Armodafinil belongs to a class of drugs known as eugeroics, which are stimulants that provide long-lasting mental arousal. Pharmacologically, armodafinil does not bind to or inhibit several receptors and enzymes potentially relevant for sleep/wake regulation. Armodafinil is not a direct- or indirect-acting dopamine receptor agonist. However, in vitro, both armodafinil and modafinil bind to the dopamine transporter and inhibit dopamine reuptake.[Medilexicon]
Dosage forms of Armodafinil
| Form | Route | Strength |
|---|---|---|
| Tablet | oral | 100 mg/1 |
| Tablet | oral | 200 mg/1 |
| Tablet | oral | 150 mg/1 |
Prescription Generics
true
International Brands
Armodafinil
Synonyms
( -2-[(R)-(diphenylmethyl)sulfinyl]acetamide R-modafinil
Manufacturers
Watson Laboratories, Inc.
CAS number
112111-43-0
UNII
V63XWA605I
State
solid
Affected organisms
Humans and other mammals
Indication of Armodafinil
Investigated for use/treatment in sleep disorders, obstructive sleep apnea, schizophrenia and schizoaffective disorders, depression, and bipolar disorders.
Toxicity of Armodafinil
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