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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Arsenic Trisenox

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Arsenic trioxide volume of distribution

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What is Arsenic trioxide

Arsenic trioxide is a chemotheraputic agent of idiopathic function used to treat leukemia that is unresponsive to first line agents. It is suspected that arsenic trisulfide induces cancer cells to undergo apoptosis. Due to the toxic nature of arsenic, this drug carries significant health risks. The enzyme thioredoxin reductase has recently been identified as a target for arsenic trioxide.

Arsenic trioxide mechanism of action

The mechanism of action of Arsenic Trioxide is not completely understood. Arsenic trioxide causes morphological changes and DNA fragmentation characteristic of apoptosis in NB4 human promyelocytic leukemia cells iin vitro /i. Arsenic trioxide also causes damage or degradation of the fusion protein PML/RAR-alpha. It is suspected that arsenic trioxide induces cancer cells to undergo apoptosis.

Dosage forms of Arsenic trioxide

Injection, solutionintravenous1 mg/mL
Solutionintravenous1 mg

Prescription Generics


International Brands



Acide Arsenieux Anhydride Arsenieux


Cephalon, Inc.

CAS number






Affected organisms

Humans and other mammals

Indication of Arsenic trioxide

For induction of remission and consolidation in patients with acute promyelocytic leukemia (APL), and whose APL is characterized by the presence of the t(15;17) translocation or PML/RAR-alpha gene expression

Toxicity of Arsenic trioxide

Symptoms of overdose include convulsions, muscle weakness and confusion.

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