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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Saphris

$61930 orally disintegrating tabs/10 mg
price without discount in nearest pharmacy. Price may vary.

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We offer free Saphris coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Asenapine every time. What are you waiting for? Claim your prescription drug card now!

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Asenapine volume of distribution

Asenapine is rapidly distributed and has a large volume of distribution (approximately 20 – 25 L/kg), indicating extensive extravascular distribution.

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2018 Statistics

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Total savings $4,735,080

What is Asenapine

Developed by Schering-Plough after its merger with Organon International, asenapine is a sublingually administered, atypical antipsychotic for treatment of schizophrenia and acute mania associated with bipolar disorder. Asenapine also belongs to the dibenzo-oxepino pyrrole class. It is also for severe post-traumatic stress disorder nightmares in soldiers as an off-label use. FDA approved on August 13, 2009.

Asenapine mechanism of action

Asenapine is an atypical antipsychotic multireceptor neuroleptic drug which shows strong 5HT2A (serotonin) and D2 (dopamine) receptor antagonism, which has been shown to enhance dopamine (DA) and acetylcholine (Ach) efflux in rat brains. Asenapine may improve cognitive function and negative symptoms in patients with schizophrenia.

Dosage forms of Asenapine

Tabletsublingual10 mg/1
Tabletsublingual10 mg
Tabletsublingual2.5 mg/1

Prescription Generics


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Affected organisms

Humans and other mammals

Indication of Asenapine

Used for treatment in psychosis, schizophrenia and schizoaffective disorders, manic disorders, and bipolar disorders as monotherapy or in combination.

Toxicity of Asenapine

In patients with schizophrenia, asenapine (in sublingual dosages of 5, 10, 15, or 20 mg twice daily) was associated with relatively small increases in the corrected QT (QTc) interval of 2-5 msec compared with placebo in a controlled and dedicated QT study; these increases were slightly lower than those observed in patients receiving quetiapine. None of the asenapine-treated patients in this study experienced a QTc-interval prolongation of 60 msec or greater compared with baseline, nor did any patient experience a QTc interval of 500 msec or greater. During short-term clinical trials in patients receiving 5 or 10 mg of asenapine sublingually twice daily, post-baseline QT-interval prolongation exceeding 500 msec was reported at similar rates for asenapine and placebo.

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What is Saphris?

Saphris is an antipsychotic drug. It works by changing the actions of chemicals in the brain. Saphris sublingual tablets are used to treat schizophrenia in adults and bipolar disorder in adults and children who are at least 10 years old.

You should not use Saphris if you are allergic to acenapine, or if you have severe liver disease. Saphris can cause serious neurological problems. Stop taking this medicine and consult a doctor immediately if you have: very hard (hard) muscles, high fever, sweating, confusion, fast or uneven heartbeat, light dizziness, tremors, twitching or uncontrolled movements of your eyes, lips, tongue , face, hands, or feet. Saphris is not approved for use in psychotic conditions associated with dementia. Assenapine may increase the risk of death in elderly people with dementia-related conditions.