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RX BIN: 015558
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Atovaquone

Malarone 62.5-25 mg ped tablet



* price without discount in nearest pharmacy. Price may vary.

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Atovaquone volume of distribution

* 0.60 0.17 L/kg

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What is Atovaquone

A hydroxynaphthoquinone that has antimicrobial activity and is being used in antimalarial protocols.

Atovaquone mechanism of action

Atovaquone is a hydroxy- 1, 4- naphthoquinone, an analog of ubiquinone, with antipneumocystis activity. The mechanism of action against iPneumocystis carinii /i has not been fully elucidated. In Plasmodium species, the site of action appears to be the cytochrome bc1 complex (Complex III). Several metabolic enzymes are linked to the mitochondrial electron transport chain via ubiquinone. Inhibition of electron transport by atovaquone will result in indirect inhibition of these enzymes. The ultimate metabolic effects of such blockade may include inhibition of nucleic acid and ATP synthesis. Atovaquone also has been shown to have good iin vitro /i activity against iToxoplasma gondii /i.

Dosage forms of Atovaquone

Mepron750mg/5mL210mL Suspension$735.00
Malarone62.5/25mg24 Tablet$50.00
Malarone250/100mg12 Tablet$76.00
Atovaquone/proguanil250/100mg12 Tablet$52.70
Atovaquone/proguanil250/100mg24 Tablet$104.20
Prescription Generics


International Brands



2-(trans-4-(P-Chlorophenyl)cyclohexyl)-3-hydroxy-1,4-naphthoquinone Acuvel


Amneal Pharmaceuticals of New York, LLC

CAS number






Affected organisms


Indication of Atovaquone

For the treatment or prevention of iPneumocystis carinii /i pneumonia in patients who are intolerant to trimethoprimsulfamethoxazole (TMP-SMX). Also indicated for the acute oral treatment of mild to moderate PCP in patients who are intolerant to TMP-SMX.

Toxicity of Atovaquone

The median lethal dose is higher than the maximum oral dose tested in mice and rats (1825 mg/kg per day). Overdoses up to 31,500 mg of atovaquone have been reported. In one such patient who also took an unspecified dose of dapsone, methemoglobinemia occurred. Rash has also been reported after overdose.

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