Save up -80% on Atovaquone
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
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2019 Price of Malarone
|$67.89||30 tablets 250mg/100mg|
|price without discount in nearest pharmacy. Price may vary.|
We offer free Atovaquone coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Atovaquone every time. What are you waiting for? Claim your prescription drug card now!
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Atovaquone volume of distribution
In a study of atovaquone population pharmacokinetics, the volume of distribution of atovaquone was 7.98 L/kg, although individual values were markedly linked to body weight; the volume of distribution shows a linear increase with increased patient body weight.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Atovaquone
A hydroxynaphthoquinone that has antimicrobial activity and is being used in antimalarial protocols.
Atovaquone mechanism of action
Atovaquone is a hydroxy- 1, 4- naphthoquinone, an analog of ubiquinone, with antipneumocystis activity. The mechanism of action against iPneumocystis carinii /i has not been fully elucidated. In Plasmodium species, the site of action appears to be the cytochrome bc1 complex (Complex III). Several metabolic enzymes are linked to the mitochondrial electron transport chain via ubiquinone. Inhibition of electron transport by atovaquone will result in indirect inhibition of these enzymes. The ultimate metabolic effects of such blockade may include inhibition of nucleic acid and ATP synthesis. Atovaquone also has been shown to have good iin vitro /i activity against iToxoplasma gondii /i.
Dosage forms of Atovaquone
Amneal Pharmaceuticals of New York, LLC
Indication of Atovaquone
For the treatment or prevention of iPneumocystis carinii /i pneumonia in patients who are intolerant to trimethoprim–sulfamethoxazole (TMP-SMX). Also indicated for the acute oral treatment of mild to moderate PCP in patients who are intolerant to TMP-SMX.
Toxicity of Atovaquone
The median lethal dose is higher than the maximum oral dose tested in mice and rats (1825 mg/kg per day). Overdoses up to 31,500 mg of atovaquone have been reported. In one such patient who also took an unspecified dose of dapsone, methemoglobinemia occurred. Rash has also been reported after overdose.
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