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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Malarone

$67.8930 tablets 250mg/100mg
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Atovaquone volume of distribution

In a study of atovaquone population pharmacokinetics, the volume of distribution of atovaquone was 7.98 L/kg, although individual values were markedly linked to body weight; the volume of distribution shows a linear increase with increased patient body weight.

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2018 Statistics

discount card

Discount Cards 16,000+

benefit

Clients Benefit 29%

savings

Total savings $4,735,080

What is Atovaquone

A hydroxynaphthoquinone that has antimicrobial activity and is being used in antimalarial protocols.

Atovaquone mechanism of action

Atovaquone is a hydroxy- 1, 4- naphthoquinone, an analog of ubiquinone, with antipneumocystis activity. The mechanism of action against iPneumocystis carinii /i has not been fully elucidated. In Plasmodium species, the site of action appears to be the cytochrome bc1 complex (Complex III). Several metabolic enzymes are linked to the mitochondrial electron transport chain via ubiquinone. Inhibition of electron transport by atovaquone will result in indirect inhibition of these enzymes. The ultimate metabolic effects of such blockade may include inhibition of nucleic acid and ATP synthesis. Atovaquone also has been shown to have good iin vitro /i activity against iToxoplasma gondii /i.

Dosage forms of Atovaquone

DrugDosageQuantityPrice
Mepron750mg/5mL210mL Suspension$735.00
Malarone62.5/25mg24 Tablet$50.00
Malarone250/100mg12 Tablet$76.00
Atovaquone/proguanil250/100mg12 Tablet$52.70
Atovaquone/proguanil250/100mg24 Tablet$104.20

Prescription Generics

true

International Brands

Atovaquone

Synonyms

2-(trans-4-(P-Chlorophenyl)cyclohexyl)-3-hydroxy-1,4-naphthoquinone Acuvel

Manufacturers

Amneal Pharmaceuticals of New York, LLC

CAS number

95233-18-4

UNII

Y883P1Z2LT

State

solid

Affected organisms

Plasmodium

Indication of Atovaquone

For the treatment or prevention of iPneumocystis carinii /i pneumonia in patients who are intolerant to trimethoprimsulfamethoxazole (TMP-SMX). Also indicated for the acute oral treatment of mild to moderate PCP in patients who are intolerant to TMP-SMX.

Toxicity of Atovaquone

The median lethal dose is higher than the maximum oral dose tested in mice and rats (1825 mg/kg per day). Overdoses up to 31,500 mg of atovaquone have been reported. In one such patient who also took an unspecified dose of dapsone, methemoglobinemia occurred. Rash has also been reported after overdose.

RX24 Drugs Disclaimer: consult your healthcare provider before buying a Atovaquone on prescription or using an RX manufacturer savings coupon. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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