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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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2019 Price of Stendra

$3056 tablets/200 mg
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Avanafil volume of distribution

In Study HP-01, the volume of distribution is in the range 47 to 83 L. In Study TA-02 volume of distribution was in the range 89 to 102 L in the dose range 50 g to 200 mg. The volume of distribution increases with body weight (Study VIVU-RAS-002).

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What is Avanafil

Avanafil is a new phosphodiesterase-5 inhibitor that is faster acting and more selective than other drugs belonging to the same class. Chemically, it is a derivative of pyrimidine and is only available as the S-enantiomer. FDA approved on April 27, 2012.

Avanafil mechanism of action

Avanafil is a selective phosphodiesterase 5 (PDE5) enzyme inhibitor used for the treatment of erectile dysfunction caused by diabetes, age induced oxidative stress or other complications. Avanafil inhibits the cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum located around the penis. Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and corpus cavernosal smooth muscle. This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum. The inhibition of phosphodiesterase type 5 (PDE5) by avanafil enhances erectile function by increasing the amount of cGMP.

Dosage forms of Avanafil

TabletOral use100 mg
TabletOral use200 mg
TabletOral use50 mg

Prescription Generics


International Brands



(S)-4-(3-Chloro-4-methoxybenzylamino)-2-(2-hydroxymethylpyrrolidin-1-yl)-N-pyrimidin-2-ylmethyl-5-pyrimidinecarboxamide Stendra



CAS number






Affected organisms

Humans and other mammals

Indication of Avanafil

Treatment of erectile dysfunction in males.

Toxicity of Avanafil

Avanafil is generally well tolerated. The most commonly reported adverse event are headache and facial flushing.

RX24 Drugs Disclaimer: consult your healthcare provider before buying a Avanafil on prescription or using an RX manufacturer savings coupon. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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What is Stendra?

Stendra relaxes the muscles in the blood vessel walls and increases blood flow to certain areas of the body. Stendra is used to treat erectile dysfunction (impotence).

Taking Stendra with some other medicines may cause a sudden and serious drop in blood pressure. Do not take Stendra if you are also taking riociguat (Adempas) or a nitrate drug, such as nitroglycerin. If you experience dizziness or nausea during sexual activity, or if you have pain, numbness, or tingling in your chest, hands, neck, or jaw, stop immediately and consult a doctor immediately. You may have a serious side effect.

Do not take Stendra more than once a day. Allow 24 hours to pass between doses. Seek medical attention or seek emergency medical care if your erection is painful or lasts longer than 4 hours. Prolonged erection (priapism) can damage the penis.

Stendra can reduce blood flow to the optic nerve of the eye, leading to sudden loss of vision. This happened in a small number of people who took this medicine called sildenafil (Viagra). Most of these people also had heart disease, diabetes, high blood pressure, high cholesterol, or some pre-existing eye problems, as well as those who smoke or are over 50. Stop using Stendra and get emergency medical help if you have you have a sudden loss of vision