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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Avanafil

$

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What is Avanafil

Avanafil is a new phosphodiesterase-5 inhibitor that is faster acting and more selective than other drugs belonging to the same class. Chemically, it is a derivative of pyrimidine and is only available as the S-enantiomer. FDA approved on April 27, 2012.

Avanafil mechanism of action

Avanafil is a selective phosphodiesterase 5 (PDE5) enzyme inhibitor used for the treatment of erectile dysfunction caused by diabetes, age induced oxidative stress or other complications. Avanafil inhibits the cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum located around the penis. Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and corpus cavernosal smooth muscle. This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum. The inhibition of phosphodiesterase type 5 (PDE5) by avanafil enhances erectile function by increasing the amount of cGMP.

Dosage forms of Avanafil

FormRouteStrength
TabletOral use100 mg
TabletOral use200 mg
TabletOral use50 mg
Prescription Generics

false

International Brands

Stendra

Synonyms

(S)-4-(3-Chloro-4-methoxybenzylamino)-2-(2-hydroxymethylpyrrolidin-1-yl)-N-pyrimidin-2-ylmethyl-5-pyrimidinecarboxamide Stendra

Manufacturers

VIVUS, Inc.

CAS number

330784-47-9

UNII

DR5S136IVO

State

solid

Affected organisms

Humans and other mammals

Indication of Avanafil

Treatment of erectile dysfunction in males.

Toxicity of Avanafil

Avanafil is generally well tolerated. The most commonly reported adverse event are headache and facial flushing.

RX24 Drugs Disclaimer: before buying a Avanafil on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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