Save up -80% on Avanafil
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2018 Price of Avanafil
* price without discount in nearest pharmacy. Price may vary.
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Avanafil volume of distribution
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Avanafil
Avanafil is a new phosphodiesterase-5 inhibitor that is faster acting and more selective than other drugs belonging to the same class. Chemically, it is a derivative of pyrimidine and is only available as the S-enantiomer. FDA approved on April 27, 2012.
Avanafil mechanism of action
Avanafil is a selective phosphodiesterase 5 (PDE5) enzyme inhibitor used for the treatment of erectile dysfunction caused by diabetes, age induced oxidative stress or other complications. Avanafil inhibits the cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum located around the penis. Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and corpus cavernosal smooth muscle. This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum. The inhibition of phosphodiesterase type 5 (PDE5) by avanafil enhances erectile function by increasing the amount of cGMP.
Dosage forms of Avanafil
|Tablet||Oral use||100 mg|
|Tablet||Oral use||200 mg|
|Tablet||Oral use||50 mg|
Humans and other mammals
Indication of Avanafil
Treatment of erectile dysfunction in males.
Toxicity of Avanafil
Avanafil is generally well tolerated. The most commonly reported adverse event are headache and facial flushing.
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