Save up -80% on Azacitidine
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2018 Price of Azacitidine
Vidaza 100 mg vial
* price without discount in nearest pharmacy. Price may vary.
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Azacitidine volume of distribution
* 76 26 L
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Azacitidine
A pyrimidine nucleoside analogue that inhibits DNA methyltransferase, impairing DNA methylation. It is also an antimetabolite of cytidine, incorporated primarily into RNA. Azacytidine has been used as an antineoplastic agent.
Azacitidine mechanism of action
Azacitidine (5-azacytidine) is a chemical analogue of the cytosine nucleoside used in DNA and RNA. Azacitidine is thought to induce antineoplastic activity via two mechanisms; inhibition of DNA methyltransferase at low doses, causing hypomethylation of DNA, and direct cytotoxicity in abnormal hematopoietic cells in the bone marrow through its incorporation into DNA and RNA at high doses, resulting in cell death. As azacitidine is a ribonucleoside, it incoporates into RNA to a larger extent than into DNA. The incorporation into RNA leads to the dissembly of polyribosomes, defective methylation and acceptor function of transfer RNA, and inhibition of the production of protein. Its incorporation into DNA leads to a covalent binding with DNA methyltransferases, which prevents DNA synthesis and subsequent cytotoxicity.
Dosage forms of Azacitidine
|Injection, powder, lyophilized, for solution||intravenous; subcutaneous||100 mg/1|
|Powder for suspension||subcutaneous||100 mg|
4-Amino-1-beta-D-ribofuranosyl-S-triazin-2(1H)-one 5 AZC
Humans and other mammals
Indication of Azacitidine
For treatment of patients with the following French-American-British myelodysplastic syndrome subtypes: refractory anemia or refractory anemia with ringed sideroblasts (if accompanied by neutropenia or thrombocytopenia or requiring transfusions), refractory anemia with excess blasts, refractory anemia with excess blasts in transformation (now classified as acute myelogenous leukemia with multilineage dysplasia), and chronic myelomonocytic leukemia.
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