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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Azacitidine

Vidaza 100 mg vial

$588.23

vial

* price without discount in nearest pharmacy. Price may vary.

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Azacitidine volume of distribution

* 76 26 L

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What is Azacitidine

A pyrimidine nucleoside analogue that inhibits DNA methyltransferase, impairing DNA methylation. It is also an antimetabolite of cytidine, incorporated primarily into RNA. Azacytidine has been used as an antineoplastic agent.

Azacitidine mechanism of action

Azacitidine (5-azacytidine) is a chemical analogue of the cytosine nucleoside used in DNA and RNA. Azacitidine is thought to induce antineoplastic activity via two mechanisms; inhibition of DNA methyltransferase at low doses, causing hypomethylation of DNA, and direct cytotoxicity in abnormal hematopoietic cells in the bone marrow through its incorporation into DNA and RNA at high doses, resulting in cell death. As azacitidine is a ribonucleoside, it incoporates into RNA to a larger extent than into DNA. The incorporation into RNA leads to the dissembly of polyribosomes, defective methylation and acceptor function of transfer RNA, and inhibition of the production of protein. Its incorporation into DNA leads to a covalent binding with DNA methyltransferases, which prevents DNA synthesis and subsequent cytotoxicity.

Dosage forms of Azacitidine

FormRouteStrength
Injection, powder, lyophilized, for solutionintravenous; subcutaneous100 mg/1
Powder for suspensionsubcutaneous100 mg
Prescription Generics

false

International Brands

Azacitidine

Synonyms

4-Amino-1-beta-D-ribofuranosyl-S-triazin-2(1H)-one 5 AZC

Manufacturers

Sandoz Inc

CAS number

320-67-2

UNII

M801H13NRU

State

solid

Affected organisms

Humans and other mammals

Indication of Azacitidine

For treatment of patients with the following French-American-British myelodysplastic syndrome subtypes: refractory anemia or refractory anemia with ringed sideroblasts (if accompanied by neutropenia or thrombocytopenia or requiring transfusions), refractory anemia with excess blasts, refractory anemia with excess blasts in transformation (now classified as acute myelogenous leukemia with multilineage dysplasia), and chronic myelomonocytic leukemia.

Toxicity of Azacitidine

One case of overdose with azacitidine was reported during clinical trials. A patient experienced diarrhea, nausea, and vomiting after receiving a single IV dose of approximately 290 mg/m2, almost 4 times the recommended starting dose.

RX24 Drugs Disclaimer: before buying a Azacitidine on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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