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RX BIN: 015558RX PCN: HTGroup ID: DDN6600Card Holder ID: DDN6600
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Bacitracin volume of distribution

Bacitracin is not absorbed from the GI tract, pleura, or synovia. The drug is rapidly and completely absorbed following global injection. A bacitracin dosage of 200-300 units/kg administered globally every 6 hr gives sustained serum concentrations of 0.2-2 ug/mL in adult patients with normal renal function. After a single global dose of 10,000-20,000 units, the maximum serum concentration occurs after 1-2 hr, and detectable amounts of bacitracin are present in the serum 6-8 hr after injection in adult patients with normal renal function. There are no data on serum concentrations of bacitracin in infants.

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Total savings $4,735,080

What is Bacitracin

Bacitracin is a mixture of related cyclic polypeptides produced by organisms of the licheniformis group of Bacillus subtilis var Tracy. Its unique name derives from the fact that the bacillus producing it was first isolated in 1943 from a knee scrape from a girl named Margaret Tracy. As a toxic and difficult-to-use antibiotic, bacitracin doesn’t work well orally. However, it is very effective topically. Bacitracin is synthesised via the so-called nonribosomal peptide synthetases (NRPSs), which means that ribosomes are not involved in its synthesis.

Bacitracin mechanism of action

Bacitracin intereferes with the dephosphorylation of the 55-carbon, biphosphate lipid transport molecule C55-isoprenyl pyrophosphate (undecaprenyl pyrophosphate), which carries the building blocks of the peptidoglycan bacterial cell wall outside the inner membrane for construction. Bacitracin binds divalent transition metal ions (Mn(II), Co(II), Ni(II), Cu(II), and Zn(II)) which binds and oxidatively cleave DNA.

Dosage forms of Bacitracin

FormRouteStrength
Kit
Ointmenttopical500 1/g
Ointmentophthalmic500 unit

Prescription Generics

false

International Brands

10 Person Ansi

Synonyms

Bacitracin a2a Bacitracin F, 1-(N-((2-(1-amino-2-methylbutyl)-4,5-dihydro-4-thiazolyl)carbonyl)-L-leucine)-

Manufacturers

Genuine First Aid LLC

CAS number

1405-87-4

UNII

58H6RWO52I

State

solid

Affected organisms

Enteric bacteria and other eubacteria

Indication of Bacitracin

For the treatment of infants with pneumonia and empyema caused by staphylococci shown to be susceptible to the drug. Also used in ointment form for topical treatment of a variety of localized skin and eye infections, as well as for the prevention of wound infections. Used against gram positive bacteria. Bacitracin is also used as an inhibitor of proteases and other enzymes. However, specific activity of bactracin’s inhibition of protein disulfide isomerase has been called into question.

Toxicity of Bacitracin

Oral, mouse: LD sub50 /sub = 3750 mg/kg.

RX24 Drugs Disclaimer: consult your healthcare provider before buying a Bacitracin on prescription or using an RX manufacturer savings coupon. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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