Save up -80% on Baclofen

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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Baclofen

Lioresal D.S. 20 mg Tablet

$1.4

tablet

* price without discount in nearest pharmacy. Price may vary.

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Baclofen volume of distribution

* 59 L

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What is Baclofen

Baclofen is a gamma-amino-butyric acid (GABA) derivative used as a skeletal muscle relaxant. Baclofen stimulates GABA-B receptors leading to decreased frequency and amplitude of muscle spasms. It is especially useful in treating muscle spasticity associated with spinal cord injury. It appears to act primarily at the spinal cord level by inhibiting spinal polysynaptic afferent pathways and, to a lesser extent, monosynaptic afferent pathways.

Baclofen mechanism of action

Baclofen is a direct agonist at GABAB receptors. The precise mechanism of action of Baclofen is not fully known. It is capable of inhibiting both monosynaptic and polysynaptic reflexes at the spinal level, possibly by hyperpolarization of afferent terminals, although actions at supraspinal sites may also occur and contribute to its clinical effect.

Dosage forms of Baclofen

DrugDosageQuantityPrice
Baclofen10mg100 Tablet$55.00
Baclofen20mg100 Tablet$79.00
Lioresal10mg100 Tablet$70.00
Lioresal DS20mg100 Tablet$195.00
Lioresal DS25mg100 Tablet$114.40
Lioresal Intrathecal2mg/mL25mL Ampule$1,308.00
Prescription Generics

true

International Brands

Apo-baclofen Tablets – 10mg

Synonyms

(+-)-Baclofen 4-Amino-3-(4-chlorophenyl)butyric acid

Manufacturers

Apotex Inc

CAS number

1134-47-0

UNII

H789N3FKE8

State

solid

Affected organisms

Humans and other mammals

Indication of Baclofen

For the alleviation of signs and symptoms of spasticity resulting from multiple sclerosis, particularly for the relief of flexor spasms and concomitant pain, clonus, and muscular rigidity.

Toxicity of Baclofen

LD sub 50 /sub =45 mg/kg (male mice, IV); LD sub 50 /sub =78 mg/kg (male rat, IV)

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