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Price of Baclofen
Lioresal D.S. 20 mg Tablet
* price without discount in nearest pharmacy. Price may vary.
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Baclofen volume of distribution
* 59 L
What is Baclofen
Baclofen is a gamma-amino-butyric acid (GABA) derivative used as a skeletal muscle relaxant. Baclofen stimulates GABA-B receptors leading to decreased frequency and amplitude of muscle spasms. It is especially useful in treating muscle spasticity associated with spinal cord injury. It appears to act primarily at the spinal cord level by inhibiting spinal polysynaptic afferent pathways and, to a lesser extent, monosynaptic afferent pathways.
Baclofen mechanism of action
Baclofen is a direct agonist at GABAB receptors. The precise mechanism of action of Baclofen is not fully known. It is capable of inhibiting both monosynaptic and polysynaptic reflexes at the spinal level, possibly by hyperpolarization of afferent terminals, although actions at supraspinal sites may also occur and contribute to its clinical effect.
Dosage forms of Baclofen
Apo-baclofen Tablets – 10mg
Humans and other mammals
Indication of Baclofen
For the alleviation of signs and symptoms of spasticity resulting from multiple sclerosis, particularly for the relief of flexor spasms and concomitant pain, clonus, and muscular rigidity.
Toxicity of Baclofen
LD sub 50 /sub =45 mg/kg (male mice, IV); LD sub 50 /sub =78 mg/kg (male rat, IV)
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