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RX BIN: 015558
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Duavee



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Bazedoxifene volume of distribution

Following intravenous administration of a 3 mg dose of bazedoxifene, the volume of distribution is 14.7 3.9 l/kg.

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What is Bazedoxifene

Bazedoxifene is a third generation selective estrogen receptor modulator (SERM), developed by Pfizer following the completion of their takeover of Wyeth Pharmaceuticals. In late 2013, Pfizer received approval for bazedoxifene as part of the combination drug DUAVEE in the prevention (not treatment) of postmenopausal osteoporosis. It is approved in the European Union (marketed in Italy and Spain) and Japan, and is in the late phases of review by the United States’ Food and Drug Administration (FDA). Bazedoxifene is yet to be approved by the FDA.

Bazedoxifene mechanism of action

Bazedoxifene belongs to a class of compounds known as selective estrogen receptor modulators (SERMs). Bazedoxifene acts as both an oestrogen-receptor agonist and/or antagonist, depending upon the cell and tissue type and target genes. Bazedoxifene decreases bone resorption and reduces biochemical markers of bone turnover to the premenopausal range. These effects on bone remodelling lead to an increase in bone mineral density (BMD), which in turn contributes to a reduction in the risk of fractures. Bazedoxifene functions primarily as an oestrogen-receptor antagonist in uterine and breast tissues.

Dosage forms of Bazedoxifene

Duavee0.45mg/20mg28 tablets$167
Duavee0.45mg/20mg30 tablets$201
Duavee0.45mg/20mg60 tablets$403
Duavee0.45mg/20mg90 tablets$651
Duavee0.45mg/20mg150 tablets$1,007
Prescription Generics


International Brands



bazedoxifene/conjugated estrogens


U.S. Pharmaceuticals

CAS number






Affected organisms

Humans and other mammals

Indication of Bazedoxifene

Investigated for use/treatment in osteoporosis and menopause.

Toxicity of Bazedoxifene

RX24 Drugs Disclaimer: before buying a Bazedoxifene on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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