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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Bazedoxifene

$

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Bazedoxifene volume of distribution

Following intravenous administration of a 3 mg dose of bazedoxifene, the volume of distribution is 14.7 3.9 l/kg.

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What is Bazedoxifene

Bazedoxifene is a third generation selective estrogen receptor modulator (SERM), developed by Pfizer following the completion of their takeover of Wyeth Pharmaceuticals. In late 2013, Pfizer received approval for bazedoxifene as part of the combination drug DUAVEE in the prevention (not treatment) of postmenopausal osteoporosis. It is approved in the European Union (marketed in Italy and Spain) and Japan, and is in the late phases of review by the United States’ Food and Drug Administration (FDA). Bazedoxifene is yet to be approved by the FDA.

Bazedoxifene mechanism of action

Bazedoxifene belongs to a class of compounds known as selective estrogen receptor modulators (SERMs). Bazedoxifene acts as both an oestrogen-receptor agonist and/or antagonist, depending upon the cell and tissue type and target genes. Bazedoxifene decreases bone resorption and reduces biochemical markers of bone turnover to the premenopausal range. These effects on bone remodelling lead to an increase in bone mineral density (BMD), which in turn contributes to a reduction in the risk of fractures. Bazedoxifene functions primarily as an oestrogen-receptor antagonist in uterine and breast tissues.

Dosage forms of Bazedoxifene

FormRouteStrength
Tablet, film coatedoral
Modified-release tabletOral use
Tablet (immediate and extended release)oral
Prescription Generics

false

International Brands

Duavee

Synonyms

bazedoxifene/conjugated estrogens

Manufacturers

U.S. Pharmaceuticals

CAS number

198481-32-2

UNII

Q16TT9C5BK

State

solid

Affected organisms

Humans and other mammals

Indication of Bazedoxifene

Investigated for use/treatment in osteoporosis and menopause.

Toxicity of Bazedoxifene

RX24 Drugs Disclaimer: before buying a Bazedoxifene on prescription, consult your healthcare provider. Content on this page is provided for informational purposes only. Any use of this information is at your own risk.

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