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2018 Price of Duavee
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Bazedoxifene volume of distribution
Following intravenous administration of a 3 mg dose of bazedoxifene, the volume of distribution is 14.7 3.9 l/kg.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Bazedoxifene
Bazedoxifene is a third generation selective estrogen receptor modulator (SERM), developed by Pfizer following the completion of their takeover of Wyeth Pharmaceuticals. In late 2013, Pfizer received approval for bazedoxifene as part of the combination drug DUAVEE in the prevention (not treatment) of postmenopausal osteoporosis. It is approved in the European Union (marketed in Italy and Spain) and Japan, and is in the late phases of review by the United States’ Food and Drug Administration (FDA). Bazedoxifene is yet to be approved by the FDA.
Bazedoxifene mechanism of action
Bazedoxifene belongs to a class of compounds known as selective estrogen receptor modulators (SERMs). Bazedoxifene acts as both an oestrogen-receptor agonist and/or antagonist, depending upon the cell and tissue type and target genes. Bazedoxifene decreases bone resorption and reduces biochemical markers of bone turnover to the premenopausal range. These effects on bone remodelling lead to an increase in bone mineral density (BMD), which in turn contributes to a reduction in the risk of fractures. Bazedoxifene functions primarily as an oestrogen-receptor antagonist in uterine and breast tissues.
Dosage forms of Bazedoxifene
Humans and other mammals
Indication of Bazedoxifene
Investigated for use/treatment in osteoporosis and menopause.
Toxicity of Bazedoxifene
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