Save up -80% on Becaplermin
|Note: this is a drug discount program, not an insurance plan.|
|RX BIN: 015558||RX PCN: HT||Group ID: DDN6600||Card Holder ID: DDN6600|
|Pharmacists and Patients support.|
2019 Price of Regranex
|$1,115.96||1 tube (15g) 0.01% gel|
|price without discount in nearest pharmacy. Price may vary.|
We offer free Regranex coupons and discounts that may help you save up to 80% off the retail price in your local pharmacy. Just print your coupon! It’s ready to use and never expire. Present your manufacturer copay card in most local pharmacies to get a discount on Becaplermin every time. What are you waiting for? Claim your prescription drug card now!
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Becaplermin volume of distribution
Diabetic patients develop a stereotypical pattern of lower extremity atherosclerotic lesions in a more peripheral distribution when compared to non-diabetic patients. However, even limbs free from overt arterial insufficiency may suffer from a number of abnormalities in the micro-circulation that contribute to local tissue hypoxia.
Discount Cards 16,000+
Clients Benefit 29%
Total savings $4,735,080
What is Becaplermin
Becaplermin is produced by recombinant DNA technology by insertion of the gene for the B chain of platelet derived growth factor (PDGF) into the yeast, Saccharomyces cerevisiae. Becaplermin has a molecular weight of approximately 25 KD and is a homodimer composed of two identical polypeptide chains that are bound together by disulfide bonds.
Becaplermin mechanism of action
Binds to the beta platelet-derived growth factor (PDGF) receptor, a tyrosine kinase receptor. PDGF is known to exist as a dimer, and activates its signaling pathway by a ligand induced receptor dimerization and autophosphorylation. PDGF receptors also contain many auto-phosphorylation sites, which serve to mediate binding of SH2 sites and subsequently signal corresponding pathways. There are five different isoforms of PDGF that activate through two different receptors (alpha and beta).
Dosage forms of Becaplermin
|Gel||Cutaneous use||0.01 %|
c-sis PDGF B-chain
Humans and other mammals
Indication of Becaplermin
For topical treatment of skin ulcers (from diabetes)
Toxicity of Becaplermin
No significant local or systemic toxicity directly attributable to becaplermin was observed following single and multiple intravenous or subcutaneous administration at doses up to 3 mg/kg in monkeys. Administration of single large intravenous doses (up to 100 mg/kg) and repeated dosing at 1 or 3 mg/kg in mice resulted in rapidly reversible vasodilation and central nervous system depression.
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