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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Beclomethasone dipropionate

Qvar 40 mcg inhaler

$15.12

g

* price without discount in nearest pharmacy. Price may vary.

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Beclomethasone dipropionate volume of distribution

The steady state volume of distribution for beclomethasone dipropionate is 20 L, and for it’s active metabolite, beclomethasone-17-monopropionate, it is much larger at 424 L.

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What is Beclomethasone dipropionate

Beclomethasone dipropionate is a prodrug of the free form, Beclomethasone (beclomethasone-17-monopropionate). An anti-inflammatory, synthetic corticosteroid, it is used topically as an anti-inflammatory agent and in aerosol form for the treatment of asthma and allergic rhinitis (seasonal and perennial). Beclometasone dipropionate is also being investigated for oral treatment in mild-to-moderate Crohn’s disease of ileal or ileal-right colonic localisation and for “topical” use mild-to-moderate graft versus host disease. It is marketed under several brand names such as Qnasl (US) and Rivanase AQ (Canada).

Beclomethasone dipropionate mechanism of action

Unbound corticosteroids cross cell membranes and bind with high affinity to specific cytoplasmic receptors. The result includes inhibition of leukocyte infiltration at the site of inflammation, interference in the function of mediators of inflammatory response, suppression of humoral immune responses, and reduction in edema or scar tissue. The antiinflammatory actions of corticosteroids are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes. For the investigated use in the treatment of GvHD or Crohn’s, beclometasone acts by binding to interleukin-13 to inhibit cytokines, which in turn inhibits inflammatory chemicals downstream.

Dosage forms of Beclomethasone dipropionate

DrugDosageQuantityPrice
Beclomethasone Dipropionate50mcg600doses Nasal Spray$52.50
Qnasl Nasal Aerosol80mcg120doses Nasal Spray$222.00
Beconase Aq Nasal50mcg600ds Nasal Spray$76.00
Quadriderm Cream0.025/1/0.5/0.1%5g Cream$17.40
Quadriderm Cream0.025/1/0.5/0.1%10g Cream$26.50
Prescription Generics

false

International Brands

Alti-beclomethasone Dipropionate Inhaler 50mcg/md

Synonyms

(11beta,16beta)-9-chloro-11-Hydroxy-16-methyl-17,21-bis(1-oxopropoxy)pregna-1,4-diene-3,20-dione 9-chloro-11beta-Hydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17,21-dipropionate

Manufacturers

Altimed Pharma Inc.

CAS number

5534-09-8

UNII

5B307S63B2

State

solid

Affected organisms

Humans and other mammals

Indication of Beclomethasone dipropionate

Used in the maintenance treatment of asthma as prophylactic therapy in patients 5 years of age and older, and in treating symptoms for allergic rhinitis (seasonal or perennial) in patients 12 years of age and older. Also being investigated for oral treatment in mild-to-moderate Crohn’s disease of ileal or ileal-right colonic localisation and for “topical” use mild-to-moderate graft versus host disease.

Toxicity of Beclomethasone dipropionate

The acute toxicity of beclometasone dipropionate is low. The only harmful effect that follows inhalation of large amounts of the drug over a short period of time is suppression of hypothalamic-pituitary-adrenal (HPA) function. Chronic: The excessive use of beclometasone dipropionate over a long period could lead to adrenal suppression.

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