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RX BIN: 015558
RX PCN: HT
Group ID: DDN6600
Card Holder ID: DDN6600

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2018 Price of Belimumab

$

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Belimumab volume of distribution

Vdss, 10 mg/kg, SLE patients = 5.29 L.

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What is Belimumab

Belimumab is an intravenous immunosupressant for the adjunctive treatment of systemic lupus erythematosus (SLE). More specifically, it is a fully human recombinant IgG1 monoclonal antibody produced from a recombinant NS0 cell line stably transfected with the belimumab heavy chain and light chain genes. It is the first biological treatment approved for the indication of SLE. Concomitant use with live or inactivated vaccines must be avoided. Belimumab was FDA approved on March 9, 2011. Belimumab consists of 2 heavy chains, and 2 light chains of the lambda subclass. Each heavy chain contains 452 amino acid residues and each light chain contains 214 amino acid residues. There are 3 post-translational modifications: a conserved N-linked glycosylation on the CH2 domain at Asn 303 of the heavy chain, the conversion of the N-terminal glutamine residue of the heavy chain into pyroglutamate, and loss of C-terminal lysine residue of the heavy chain.

Belimumab mechanism of action

Belimumab selectively binds to soluble human B lymphocyte stimulator protein (BLyS) so that BLyS is unable to bind to receptors on B lymphocytes. The binding of BLyS to its receptor is essential for the survival of B lymphocytes. Consequently, belimumab reduces B-cell mediated immunity and the autoimmune response.

Dosage forms of Belimumab

FormRouteStrength
Injection, powder, lyophilized, for solutionintravenous120 mg/1.5mL
Injection, powder, lyophilized, for solutionintravenous400 mg/5mL
Powder for concentrate for solution for infusionIntravenous use120 mg
Prescription Generics

false

International Brands

Benlysta

Synonyms

Manufacturers

Human Genome Sciences, Inc.

CAS number

356547-88-1

UNII

73B0K5S26A

State

liquid

Affected organisms

Humans and other mammals

Indication of Belimumab

Adjunct treatment for auto-antibody-positive active systemic lupus erythematosus.

Toxicity of Belimumab

The most commonly-reported adverse reactions, occurring in 5% of patients in clinical trials were nausea, diarrhea, pyrexia, nasopharyngitis, bronchitis, insomnia, pain in extremity, depression, migraine, and pharyngitis. The most common serious adverse reactions were serious infections.

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